Development and validation of modified Liaoning score for predicting the prognosis of liver cirrhosis: a retrospective, international multicenter, observational study

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Autor(es): dc.contributorGeneral Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorThe 960th Hospital of the PLA-
Autor(es): dc.contributorChina Medical University-
Autor(es): dc.contributorRajagiri Hospital-
Autor(es): dc.contributorThe First Affiliated Hospital of Fujian Medical University-
Autor(es): dc.creatorSong, Xiaoting-
Autor(es): dc.creatorRomeiro, Fernando Gomes-
Autor(es): dc.creatorWang, Jing-
Autor(es): dc.creatorYin, Yue-
Autor(es): dc.creatorPhilips, Cyriac Abby-
Autor(es): dc.creatorYang, Xinyi-
Autor(es): dc.creatorLiu, Xiaofeng-
Autor(es): dc.creatorWu, Wenming-
Autor(es): dc.creatorBernardinelli, Marcos Vinícius Tiveli-
Autor(es): dc.creatorSantos de Souza, Roger-
Autor(es): dc.creatorTheruvath, Arif Hussain-
Autor(es): dc.creatorLin, Su-
Autor(es): dc.creatorQi, Xingshun-
Data de aceite: dc.date.accessioned2025-08-21T20:36:07Z-
Data de disponibilização: dc.date.available2025-08-21T20:36:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/17474124.2024.2320238-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298360-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298360-
Descrição: dc.descriptionBackground: Liaoning score has been developed and validated to predict the risk of esophageal varices in liver cirrhosis. This study aimed to further modify the Liaoning score by combining clinical and laboratory parameters to predict the long-term outcome of cirrhotic patients. Methods: First, 474 cirrhotic patients were retrospectively enrolled from Shenyang, China as the training cohort. Independent predictors for death were identified by competing risk analyses, and then a new prognostic model, called as modified Liaoning score, was developed. Its performance was externally validated at three centers from Fuzhou, China (n = 1944), Jinan, China (n = 485), and São Paulo, Brazil (n = 221). Results: Age, total bilirubin (TBIL), albumin (ALB), serum creatinine (SCr), and Liaoning score were independently associated with death in the training cohort. Modified Liaoning score = 0.159×Liaoning score + 0.010×TBIL(µmol/L)+0.029×age(years)+0.011×SCr(µmol/L)-0.037×ALB(g/L). The area under curve of modified Liaoning score was 0.714 (95%CI = 0.655–0.773), which was higher than that of Child-Pugh score (0.707, 95%CI = 0.645–0.770), MELD score (0.687, 95%CI = 0.623–0.751), and Liaoning score (0.583, 95%CI = 0.513–0.654). A modified Liaoning score of ≥ 1.296 suggested a higher cumulative incidence of death in liver cirrhosis (p < 0.001). Modified Liaoning score still had the highest prognostic performance in Chinese and Brazilian validation cohorts. Conclusions: Modified Liaoning score can be considered for predicting the long-term outcome of cirrhotic patients.-
Descrição: dc.descriptionLiver Cirrhosis Study Group Department of Gastroenterology General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School Universidade Estadual Paulista (UNESP-
Descrição: dc.descriptionDepartment of Gastroenterology The 960th Hospital of the PLA-
Descrição: dc.descriptionPostgraduate College China Medical University-
Descrição: dc.descriptionClinical and Translational Hepatology The Liver Institute Center of Excellence in GI Sciences Rajagiri Hospital, Kerala-
Descrição: dc.descriptionLiver Research Center The First Affiliated Hospital of Fujian Medical University-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School Universidade Estadual Paulista (UNESP-
Formato: dc.format121-128-
Idioma: dc.languageen-
Relação: dc.relationExpert Review of Gastroenterology and Hepatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectesophageal varices-
Palavras-chave: dc.subjectLiaoning score-
Palavras-chave: dc.subjectLiver cirrhosis-
Palavras-chave: dc.subjectportal hypertension-
Palavras-chave: dc.subjectprognosis-
Título: dc.titleDevelopment and validation of modified Liaoning score for predicting the prognosis of liver cirrhosis: a retrospective, international multicenter, observational study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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