Antifungal activity of guanidine compounds

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorEguiluz, Alexandra Daniela Barrios-
Autor(es): dc.creatorOrlandi, Caroline Barcelos Costa-
Autor(es): dc.creatorDo Espírito Santo, Rafael Días-
Autor(es): dc.creatorZampieri, Eduardo Henrique-
Autor(es): dc.creatordos Anjos, Luana Ribeiro-
Autor(es): dc.creatorGiannini, Maria José Soares Mendes-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Autor(es): dc.creatorValentini, Sandro Roberto-
Autor(es): dc.creatorZanelli, Cleslei Fernando-
Autor(es): dc.creatorde Souza-Moreira, Tatiana Maria-
Autor(es): dc.creatorGonzález, Eduardo René Pérez-
Data de aceite: dc.date.accessioned2025-08-21T23:12:17Z-
Data de disponibilização: dc.date.available2025-08-21T23:12:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s42770-025-01625-w-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298333-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298333-
Descrição: dc.descriptionGuanidinic compounds are a class of compounds distributed in nature but also synthesized in vitro with a wide variety of applicability. One of the potentials of those molecules is antimicrobial activity. In that sense, although mainly limited to immunocompromised people, fungi pathogens are a cause of concern, even more so after the COVID-19 pandemic. Susceptible groups and increased geographical distribution, besides drug toxicity, resistance, and high costs, made the World Health Organization (WHO) establish a guideline for research and public health politics against different fungi opportunist agents. Our present work evaluated the antifungal activity of 11 guanidine compounds (one of them synthesized for the first time) against six fungi species in the WHO Fungi Priority Pathogens List and their potential for antimicrobial selectivity. The newly synthesized compound, named LQOF-G2-S, was successfully obtained and chemically characterized as spermidine tri-substituted by guanidine moieties in benzylamine-4-bromoaniline groups, and it presented the best antifungal activity and selectivity among the others. It was the only compound active against Candida spp.; however, its activity was more promising against Cryptococcus neoformans, Cryptococcus gattii, and even more against Paracoccidioides brasiliensis and Paracoccidioides lutzii, with a selective index higher than 10. The LQOF-G2-S potential opened up the opportunity to design and evaluate other similar compounds, contributing to finding new effective, less toxic, and more affordable compounds for fungi treatment.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University-UNESP, Rod. Araraquara-Jau Km 1, São Paulo-
Descrição: dc.descriptionFine Organic Chemistry Lab School of Sciences and Technology São Paulo State University-UNESP, Roberto Simonsen, 305, São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University-UNESP, Rod. Araraquara-Jau Km 1, São Paulo-
Descrição: dc.descriptionFine Organic Chemistry Lab School of Sciences and Technology São Paulo State University-UNESP, Roberto Simonsen, 305, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectSpermidine-
Palavras-chave: dc.subjectWHO fungi priority pathogens list-
Título: dc.titleAntifungal activity of guanidine compounds-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.