PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstitute of Orofacial Osteogenesis Rehabilitation S/S Ltda.-
Autor(es): dc.contributorUniversity of Marilia-
Autor(es): dc.creatorSantos-Silva, Thamires-
Autor(es): dc.creatorViana, Inácio Silva-
Autor(es): dc.creatorQueiroz, Andrea Barros Piazzon S.-
Autor(es): dc.creatorde Oliveira, Fabrício Singaretti-
Autor(es): dc.creatorHorvath-Pereira, Bianca de Oliveira-
Autor(es): dc.creatorda Silva-Júnior, Leandro Norberto-
Autor(es): dc.creatorAraujo, Michelle Silva-
Autor(es): dc.creatorCanola, Paulo Alescio-
Autor(es): dc.creatorDias, Luís Gustavo Gosuen G.-
Autor(es): dc.creatorSoares, Marcelo Melo-
Autor(es): dc.creatorMiglino, Maria Angelica-
Data de aceite: dc.date.accessioned2025-08-21T22:30:07Z-
Data de disponibilização: dc.date.available2025-08-21T22:30:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb15100311-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298323-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298323-
Descrição: dc.descriptionBone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for bone regeneration. In this context, 3D printing techniques using poly-L-lactic acid/graphene oxide (PLLA/GO) aim to address this issue by creating customized scaffolds combined with canine placenta hydrogel and mesenchymal stem cells for use in goat mandibles, compared to a control group using titanium plate fixation. Ten canine placentas were decellularized and characterized using histological techniques. A hydrogel derived from the canine placenta extracellular matrix (cpECM) was produced to improve cell attachment to the scaffolds. In vitro cytotoxicity and cell adhesion to the cpECM hydrogel were assessed by scanning electron microscopy (SEM). The resulting biomaterials, cpECM hydrogel and PLLA/GO scaffolds, maintained their functional structure and supported cell adhesion, maintenance, and proliferation in vitro. Thermography showed that PLLA/GO scaffolds with cpECM hydrogel performed effectively, similar to the control group. Computed tomography scans revealed bone calluses, suggesting an ongoing repair process. These findings demonstrate the innovative technological potential of these materials for use in surgical interventions. Future studies on PLLA/GO scaffolds will provide further insights into their effects on goat models.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Surgery School of Veterinary Medicine and Animal Science University of São Paulo, São Paulo, SP-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery School of Agricultural and Veterinary Sciences São Paulo State University, Jaboticabal Campus, SP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology School of Agricultural and Veterinary Sciences São Paulo State University, Jaboticabal Campus, SP-
Descrição: dc.descriptionInstitute of Orofacial Osteogenesis Rehabilitation S/S Ltda., SP-
Descrição: dc.descriptionDepartment of Animal Anatomy University of Marilia, Mirante, SP-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery School of Agricultural and Veterinary Sciences São Paulo State University, Jaboticabal Campus, SP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology School of Agricultural and Veterinary Sciences São Paulo State University, Jaboticabal Campus, SP-
Descrição: dc.descriptionCAPES: 88887.488264/2020-00-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomaterials-
Palavras-chave: dc.subjectbone defect-
Palavras-chave: dc.subjectcomputed tomography scans-
Palavras-chave: dc.subjectdecellularization-
Palavras-chave: dc.subjecttissue engineering-
Título: dc.titlePLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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