In Vitro Adhesion and Invasion Rates of Staphylococcus aureus Isolated from Mastitic Cows Are Modulated by the agr System and MSCRAMM Genes

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorMichigan State University-
Autor(es): dc.creatorBonsaglia, Erika Carolina Romão-
Autor(es): dc.creatorRossi, Bruna Fernanda-
Autor(es): dc.creatorPossebon, Fabio Sossai-
Autor(es): dc.creatorSilva, Nathalia Cristina Cirone-
Autor(es): dc.creatorGonçalves, Juliano Leonel-
Autor(es): dc.creatorCastilho, Ivana Giovannetti-
Autor(es): dc.creatorFernandes Junior, Ary-
Autor(es): dc.creatorSantos, Marcos Veiga dos-
Autor(es): dc.creatorRall, Vera Lúcia Mores-
Data de aceite: dc.date.accessioned2025-08-21T15:10:54Z-
Data de disponibilização: dc.date.available2025-08-21T15:10:54Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/vetsci12030270-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298319-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298319-
Descrição: dc.descriptionMastitis, an inflammatory condition of the udder, can be caused by the entry of Staphylococcus aureus, whose adhesion to the mammary epithelial cells is influenced by virulence factors such as microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and the accessory gene regulator (agr) system. Our goal was to determine the adhesion and invasion rates of S. aureus isolates from clinical (mild and moderate) and subclinical mastitis and to assess the impact of MSCRAMM genes and agr types on disease severity. Clinical isolates predominantly carried agrII (p < 0.0083) and multiple MSCRAMM genes, correlating with high adhesion capacity but reduced invasion capacity regardless of clinical severity. Remarkably, subclinical isolates, mainly agr-negative (85.7%), showed increased cellular invasion (p < 0.0001), possibly due to reduced expression of agr-mediated virulence factors. These findings contribute to the understanding of the pathogen–host dynamics in bovine mastitis and highlight the importance of both MSCRAMMs and the agr system in modulating disease severity. These insights can inform targeted interventions for mastitis prevention and treatment.-
Descrição: dc.descriptionDepartment of Animal Nutrition and Production School of Veterinary Medicine and Animal Sciences University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine Sao Paulo State University-
Descrição: dc.descriptionInstitute of Biotechnology Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Food Science and Nutrition School of Food Engineering University of Campinas (UNICAMP)-
Descrição: dc.descriptionVeterinary Diagnostic Laboratory College of Veterinary Medicine Michigan State University-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine Sao Paulo State University-
Descrição: dc.descriptionInstitute of Biotechnology Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectclinical mastitis-
Palavras-chave: dc.subjectdairy cow-
Palavras-chave: dc.subjectmastitis severity-
Palavras-chave: dc.subjectpathogenicity-
Palavras-chave: dc.subjectsubclinical mastitis-
Título: dc.titleIn Vitro Adhesion and Invasion Rates of Staphylococcus aureus Isolated from Mastitic Cows Are Modulated by the agr System and MSCRAMM Genes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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