DElaying Disease Progression In COPD with Early Initiation of Dual Bronchodilator or Triple Inhaled PharmacoTherapy (DEPICT): A Predictive Modelling Approach

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Manchester-
Autor(es): dc.contributorManchester University NHS Foundation Trust-
Autor(es): dc.contributorHospital General de Agudos Dr. J. A. Fernández-
Autor(es): dc.contributorUniversidad Anáhuac-
Autor(es): dc.contributorCIPTIR-
Autor(es): dc.contributorEge University Faculty of Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGSK-
Autor(es): dc.contributorMcMaster University-
Autor(es): dc.creatorSingh, Dave-
Autor(es): dc.creatorLitewka, Diego-
Autor(es): dc.creatorPáramo, Rafael-
Autor(es): dc.creatorRendon, Adrian-
Autor(es): dc.creatorSayiner, Abdullah-
Autor(es): dc.creatorTanni, Suzana E.-
Autor(es): dc.creatorAcharya, Sudeep-
Autor(es): dc.creatorAggarwal, Bhumika-
Autor(es): dc.creatorIsmaila, Afisi S.-
Autor(es): dc.creatorSharma, Raj-
Autor(es): dc.creatorDaley-Yates, Peter-
Data de aceite: dc.date.accessioned2025-08-21T16:43:12Z-
Data de disponibilização: dc.date.available2025-08-21T16:43:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12325-023-02583-1-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298292-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298292-
Descrição: dc.descriptionIntroduction: Clinical studies demonstrate an accelerated decline in lung function in patients with moderate chronic obstructive pulmonary disease (COPD) (Global Initiative for Chronic Obstructive Lung Disease [GOLD] grade 2) versus severe and very severe COPD (GOLD grades 3 and 4). This predictive modelling study assessed the impact of initiating pharmacotherapy earlier versus later on long-term disease progression in COPD. Methods: The modelling approach used data on decline in forced expiratory volume in 1 s (FEV1) extracted from published studies to develop a longitudinal non-parametric superposition model of lung function decline with progressive impact of exacerbations from 0 per year to 3 per year and no ongoing pharmacotherapy. The model simulated decline in FEV1 and annual exacerbation rates from age 40 to 75 years in COPD with initiation of long-acting anti-muscarinic antagonist (LAMA)/long-acting beta2-agonist (LABA) (umeclidinium (UMEC)/vilanterol (VI)) or triple (inhaled corticosteroid (ICS)/LAMA/LABA; fluticasone furoate (FF)/UMEC/VI) therapy at 40, 55 or 65 years of age. Results: Model-predicted decline in FEV1 showed that, compared with ‘no ongoing’ therapy, initiation of triple or LAMA/LABA therapy at age 40, 55 or 65 years preserved an additional 469.7 mL or 236.0 mL, 327.5 mL or 203.3 mL, or 213.5 mL or 137.5 mL of lung function, respectively, by the age of 75. The corresponding average annual exacerbation rates were reduced from 1.57 to 0.91, 1.06 or 1.23 with triple therapy or to 1.2, 1.26 and 1.4 with LAMA/LABA therapy when initiated at 40, 55 or 65 years of age, respectively. Conclusions: This modelling study suggests that earlier initiation of LAMA/LABA or triple therapy may have positive benefits in slowing disease progression in patients with COPD. Greater benefits were demonstrated with early initiation therapy with triple versus LAMA/LABA.-
Descrição: dc.descriptionGlaxoSmithKline-
Descrição: dc.descriptionGlaxoSmithKline foundation-
Descrição: dc.descriptionCentre for Respiratory Medicine and Allergy Institute of Inflammation and Repair Manchester Academic Health Science Centre University of Manchester-
Descrição: dc.descriptionManchester University NHS Foundation Trust-
Descrição: dc.descriptionPulmonology Unit Hospital General de Agudos Dr. J. A. Fernández-
Descrição: dc.descriptionUniversidad Anáhuac-
Descrição: dc.descriptionUniversidad Autónoma de Nuevo León Servicio de Neumología CIPTIR, NL-
Descrição: dc.descriptionDepartment of Chest Diseases Ege University Faculty of Medicine-
Descrição: dc.descriptionDepartment of Botucatu Medical School Universidade Estadual Paulista-
Descrição: dc.descriptionEmerging Markets GSK-
Descrição: dc.descriptionValue Evidence and Outcomes GSK-
Descrição: dc.descriptionDepartment of Health Research Methods Evidence and Impact McMaster University-
Descrição: dc.descriptionGSK-
Descrição: dc.descriptionClinical Pharmacology and Experimental Medicine GSK, Brentford-
Descrição: dc.descriptionDepartment of Botucatu Medical School Universidade Estadual Paulista-
Formato: dc.format4282-4297-
Idioma: dc.languageen-
Relação: dc.relationAdvances in Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChronic obstructive pulmonary disease (COPD)-
Palavras-chave: dc.subjectCOPD exacerbation-
Palavras-chave: dc.subjectDual bronchodilator therapy (LAMA/LABA)-
Palavras-chave: dc.subjectGOLD grades-
Palavras-chave: dc.subjectLung function decline-
Palavras-chave: dc.subjectTriple therapy (ICS/LAMA/LABA)-
Título: dc.titleDElaying Disease Progression In COPD with Early Initiation of Dual Bronchodilator or Triple Inhaled PharmacoTherapy (DEPICT): A Predictive Modelling Approach-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.