Non-radioactive strontium as a supplement to enhance osseointegration

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSection of Oral Radiology-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFaculty of Odontology-
Autor(es): dc.creatorScardueli, Cassio Rocha-
Autor(es): dc.creatorSpin-Neto, Rubens-
Autor(es): dc.creatorOliveira, Guilherme José Lopes Pimentel-
Autor(es): dc.creatorStavropoulos, Andreas-
Autor(es): dc.creatorMarcantonio, Rosemary Adriana Chierici-
Autor(es): dc.creatorMarcantonio, Elcio-
Data de aceite: dc.date.accessioned2025-08-21T18:47:40Z-
Data de disponibilização: dc.date.available2025-08-21T18:47:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1807-2577.02624-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298284-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298284-
Descrição: dc.descriptionIntroduction: Due to its positive results on bone tissue, strontium also began to be used as an adjuvant in bone neoformation processes, mainly maxillofacial surgical procedures. Objective: To assess if the nonradioactive strontium (Sr) supplementation enhances the osseointegration of titanium implants in rats. Material and method: Seventy male rats (Rattus Norvegicus) were randomly divided into 5 groups, according to the systemic supplementation: Control-saline solution; SRAN50-strontium ranelate (SRAN) 50mg/kg/day; SRAN625-SRAN 625mg/kg/day; SCAR/SCHL30-strontium carbonate and strontium chloride (SCAR/SCHL) 30mg/kg/day; SCAR/SCHL365-SCAR/SCHL 365mg/kg/day. The drugs were administered via gavage, once a day, starting 15 days before surgery (1 titanium implant in each tibia), and persisted for 15 or 60 days. The right tibiae were used for biomechanical (removal torque) and immunohistochemical (Osteocalcin – OCN, and bone morphogenetic protein-BMP-2) evaluation. The left were used for microtomographic, and histomorphometric evaluation. Result: Increased removal torque for SRAN625 and SCAR/SCHL365 were observed when compared with the Control, in 15 days. However, no differences were found in the 60-days period among the groups. Microtomographic evaluation showed larger bone volume at 60 days, compared to 15 days, for all groups but SCAR/SCHL30. When all groups were compared, no differences were seen in the 15-days period, while in the 60-days SRAN625 and SCAR/SCHL365 were statistically higher than the Control. In the immunohistochemical analysis, higher doses (SRAN625 and SCAR/SCHL365) led to an increase of BMP-2 in 15 days. Histomorphometric analysis revealed no differences among the groups regarding bone-to-implant-contact and bone area around the implant threads. Conclusion: This study suggests that higher concentrations of systemic Sr lead to variably improved osseointegration-related parameters regarding the biomechanical and microtomographic evaluation.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Odontologia de Araraquara, SP-
Descrição: dc.descriptionAarhus University Department of Dentistry Section of Oral Radiology-
Descrição: dc.descriptionUFU – Universidade Federal de Uberlândia Faculdade de Odontologia de Uberlândia Departamento de Periodontia, MG-
Descrição: dc.descriptionMalmo University Faculty of Odontology Department of Periodontology and Community Dentistry-
Descrição: dc.descriptionUNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Odontologia de Araraquara Departamento de Diagnóstico e Cirurgia, SP-
Descrição: dc.descriptionUNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Odontologia de Araraquara, SP-
Descrição: dc.descriptionUNESP – Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Odontologia de Araraquara Departamento de Diagnóstico e Cirurgia, SP-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationRevista de Odontologia da UNESP-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone remodeling-
Palavras-chave: dc.subjectimplants-
Palavras-chave: dc.subjectosseointegration-
Palavras-chave: dc.subjectStrontium-
Palavras-chave: dc.subjectsystemic use-
Título: dc.titleNon-radioactive strontium as a supplement to enhance osseointegration-
Título: dc.titleEstrôncio não radioativo como suplemento para melhorar a osseointegração-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.