Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorConceição, Mariana-
Autor(es): dc.creatorDi Filippo, Leonardo Delello-
Autor(es): dc.creatorDuarte, Jonatas Lobato-
Autor(es): dc.creatorBeserra, Fernando Pereira-
Autor(es): dc.creatorGremião, Maria Palmira Daflon-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T16:06:07Z-
Data de disponibilização: dc.date.available2025-08-21T16:06:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbih.2024.100894-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298227-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298227-
Descrição: dc.descriptionDrug repurposing, also known as drug repositioning, involves identifying new applications for drugs whose effects in a disease are already established. Doxycycline, a broad-spectrum antibiotic belonging to the tetracycline class, has demonstrated potential activity against neurodegenerative diseases like Alzheimer's and Parkinson's. However, despite its promise, the repurposed use of doxycycline encounters challenges in reaching the brain in adequate concentrations to exert its effects. To address this issue, nanostructured systems offer an innovative approach that can enhance brain targeting and the desired therapeutic outcomes. This review discusses the advances in doxycycline repurposing for Alzheimer's disease, presenting physicochemical and biological aspects that permeate doxycycline's repositioning and its application in nano-based delivery systems.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Araraquara-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP), Ribeirão Preto-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Araraquara-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionFAPESP: #2023/04282-2-
Descrição: dc.descriptionCAPES: 001 88887.801886/2023-00-
Descrição: dc.descriptionCAPES: 2023/04282-2-
Idioma: dc.languageen-
Relação: dc.relationBrain, Behavior, and Immunity - Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlzheimer-
Palavras-chave: dc.subjectDoxycycline-
Palavras-chave: dc.subjectDrug delivery-
Palavras-chave: dc.subjectDrug repositioning-
Palavras-chave: dc.subjectDrug repurposing-
Palavras-chave: dc.subjectNanotechnology-
Título: dc.titleRepurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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