Combined impact of pesticides on mono- and bilayer lipid membranes

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of North of Tocantins-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMorato, Luis Fernando do Carmo-
Autor(es): dc.creatorRuiz, Gilia Cristine Marques-
Autor(es): dc.creatorLessa, Carlos Junior Amorim-
Autor(es): dc.creatorOlivier, Danilo da Silva-
Autor(es): dc.creatorAmaral, Marcos Serrou do-
Autor(es): dc.creatorGomes, Orisson Ponce-
Autor(es): dc.creatorPazin, Wallance Moreira-
Autor(es): dc.creatorBatagin-Neto, Augusto-
Autor(es): dc.creatorOliveira, Osvaldo N.-
Autor(es): dc.creatorConstantino, Carlos José Leopoldo-
Data de aceite: dc.date.accessioned2025-08-21T17:28:10Z-
Data de disponibilização: dc.date.available2025-08-21T17:28:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.chemphyslip.2025.105474-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298221-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298221-
Descrição: dc.descriptionThe increased use of agrochemicals in crop production raises concerns about the risk of combined pesticide exposure through water and food, potentially leading to a ‘cocktail effect’ with synergistic impacts on human health. To investigate such effects, we used the pesticides acephate and diuron interacting with a mimetic system of the cell membrane, composed of lipid monolayers. These mimetic systems were composed by a mixture of POPC, cholesterol and sphingomyelin (70/20/10 mol%), respectively, close to the composition found in mammalian membranes. Results from Langmuir monolayers, including surface pressure-area isotherms, polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS), and Brewster angle microscopy (BAM), showed that the pesticides interact predominantly with the polar head region of the lipids, a finding supported by density functional theory (DFT) calculations and molecular dynamics simulations. The cocktail had a similar effect in π-A isotherms; however, PM-IRRAS data suggests a stronger effect of the cocktail on the ternary monolayer at the molecular level, once the pesticide mixture changed the conformation and orientation of the headgroup and disturbed the hydrocarbon chain. These results evidence the impact of the ‘cocktail effect’ on lipid membranes, highlighting potential health risks associated with pesticide mixtures.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Technology and Applied Sciences Presidente Prudente, SP-
Descrição: dc.descriptionIntegrated Sciences Center Campus Cimba Federal University of North of Tocantins, TO-
Descrição: dc.descriptionInstitute of Physics Federal University of Mato Grosso do Sul, MS-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Campus Bauru, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Sciences and Engineering Campus Itapeva, SP-
Descrição: dc.descriptionSao Carlos Institute of Physics University of Sao Paulo (USP), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Technology and Applied Sciences Presidente Prudente, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Campus Bauru, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Sciences and Engineering Campus Itapeva, SP-
Descrição: dc.descriptionFAPESP: 2018/22214-6-
Descrição: dc.descriptionFAPESP: 2020/15185-0-
Descrição: dc.descriptionCNPq: 306501/2022-8-
Descrição: dc.descriptionCNPq: 311368/2022-0-
Descrição: dc.descriptionCAPES: 88887.817531/2023-00-
Idioma: dc.languageen-
Relação: dc.relationChemistry and Physics of Lipids-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2D assembly-
Palavras-chave: dc.subjectBilayer-
Palavras-chave: dc.subjectBiointerfaces-
Palavras-chave: dc.subjectLangmuir film-
Palavras-chave: dc.subjectPesticides-
Palavras-chave: dc.subjectTheoretical-experimental analyses-
Título: dc.titleCombined impact of pesticides on mono- and bilayer lipid membranes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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