The Synthetic Peptide GA-Hecate and Its Analogs Inhibit Multiple Steps of the Chikungunya Virus Infection Cycle In Vitro

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorThe Rockefeller University-
Autor(es): dc.contributorUniversity of Tartu-
Autor(es): dc.creatorAyusso, Gabriela Miranda-
Autor(es): dc.creatorda Silva Sanches, Paulo Ricardo-
Autor(es): dc.creatorCarvalho, Tamara-
Autor(es): dc.creatorSantos, Igor Andrade-
Autor(es): dc.creatorMartins, Daniel Oliveira Silva-
Autor(es): dc.creatorLima, Maria Letícia Duarte-
Autor(es): dc.creatorda Conceição, Pâmela Jóyce Previdelli-
Autor(es): dc.creatorBittar, Cíntia-
Autor(es): dc.creatorMerits, Andres-
Autor(es): dc.creatorCilli, Eduardo Maffud-
Autor(es): dc.creatorJardim, Ana Carolina Gomes-
Autor(es): dc.creatorRahal, Paula-
Autor(es): dc.creatorCalmon, Marilia Freitas-
Data de aceite: dc.date.accessioned2025-08-21T17:55:16Z-
Data de disponibilização: dc.date.available2025-08-21T17:55:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph16101389-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298169-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298169-
Descrição: dc.descriptionChikungunya virus (CHIKV) belongs to the Alphavirus genus and is responsible for significant outbreaks worldwide. Currently, there is no approved antiviral therapy against CHIKV. Bioactive peptides have great potential for new drug development. Here, we evaluated the antiviral activity of the synthetic peptide GA-Hecate and its analogs PSSct1905 and PSSct1910 against CHIKV infection. Initial screening showed that all three peptides inhibited the CHIKV replication cycle in baby hamster kidney fibroblast cells (BHK-21) and human hepatocarcinoma epithelial cells (Huh-7). GA-Hecate and its analog PSSct1905 were the most active, demonstrating suppression of viral infection by more than 91%. The analog PSSct1905 exhibited a protective effect in cells against CHIKV infection. We also observed that the analogs PSSct1905 and PSSct1910 affected CHIKV entry into both cell lines, inhibiting viral attachment and internalization. Finally, all tested compounds presented antiviral activity on the post-entry steps of CHIKV infection in all cells evaluated. In conclusion, this study highlights the potential of the peptide GA-Hecate and its analogs as novel anti-CHIKV compounds targeting different stages of the viral replication cycle, warranting the development of GA-Hecate-based compounds with broad antiviral activity.-
Descrição: dc.descriptionInstitute of Biosciences Letters and Exact Sciences São Paulo State University, SP-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, SP-
Descrição: dc.descriptionInstitute of Biomedical Sciences Federal University of Uberlândia, MG-
Descrição: dc.descriptionLaboratory of Molecular Immunology The Rockefeller University-
Descrição: dc.descriptionInstitute of Technology University of Tartu-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, SP-
Descrição: dc.descriptionInstitute of Biosciences Letters and Exact Sciences São Paulo State University, SP-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanalogs-
Palavras-chave: dc.subjectantiviral-
Palavras-chave: dc.subjectchikungunya-
Palavras-chave: dc.subjectpeptides-
Título: dc.titleThe Synthetic Peptide GA-Hecate and Its Analogs Inhibit Multiple Steps of the Chikungunya Virus Infection Cycle In Vitro-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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