Cold Atmospheric Pressure Plasma May Prevent Oral Mucositis-Related Candidemia in Chemotherapy-Treated Rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSampaio, Aline da Graça-
Autor(es): dc.creatorMilhan, Noala Vicensoto Moreira-
Autor(es): dc.creatordo Nascimento, Fellype-
Autor(es): dc.creatorKostov, Konstantin Georgiev-
Autor(es): dc.creatorKoga-Ito, Cristiane Yumi-
Data de aceite: dc.date.accessioned2025-08-21T20:14:40Z-
Data de disponibilização: dc.date.available2025-08-21T20:14:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms252111496-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298167-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298167-
Descrição: dc.descriptionOral mucositis associated with candidiasis can causes systemic candidemia, posing a risk to cancer patients administered antineoplastic therapy. Cold atmospheric pressure plasma jets (CAPPJs) have antifungal and anti-inflammatory properties. This study evaluated the effects CAPPJs in preventing systemic fungal dissemination in a murine model of oral mucositis associated with candidiasis. Forty Wistar rats were divided into groups: CAPPJs (treated) and non-treated controls (for comparison), with subgroups subject to 24 and 72 h of treatment (n = 10 each). Four cycles of chemotherapy (cisplatin and 5-fluorouracil (5-FU)) were administered, followed by oral inoculation of Candida albicans for 3 days. Mucosal damage was induced on the lateral side of tongue with 50% acetic acid. CAPPJ treatment was performed on the lesion for 5 min (2 days). Body weight was assessed daily. Fungal dissemination was conducted using organ macerates and plated on Sabouraud Agar with chloramphenicol. Blood samples were obtained for blood count tests. Chemotherapy affected the general health of the animals, as evidenced by body weight loss. Treatment with CAPPJs showed an inhibitory effect on C. albicans, with a significant reduction in fungal recovery from the tongue after 24 h (p < 0.05). Interestingly, systemic fungal dissemination was significantly reduced after 24 and 72 h of treatment when compared to control (p < 0.05). Taken together, these results suggest that CAPPJs have potential for clinical application in patients with oral mucositis at risk of candidemia.-
Descrição: dc.descriptionOral Health Applied Science Program Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFaculty of Engineering in Guaratinguetá São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Environment Engineering Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionOral Health Applied Science Program Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFaculty of Engineering in Guaratinguetá São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Environment Engineering Institute of Science and Technology São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcold atmospheric pressure plasma jets-
Palavras-chave: dc.subjectfungemia-
Palavras-chave: dc.subjectmucositis-
Palavras-chave: dc.subjectplasma gases-
Título: dc.titleCold Atmospheric Pressure Plasma May Prevent Oral Mucositis-Related Candidemia in Chemotherapy-Treated Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.