Comet assay as a suitable biomarker for in vivo oral carcinogenesis: a systematic review

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUFOP-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUFRS-
Autor(es): dc.creatorGuedes Pinto, Thiago-
Autor(es): dc.creatorde Souza, Daniel Vitor-
Autor(es): dc.creatorda Silva, Glenda Nicioli-
Autor(es): dc.creatorSalvadori, Daisy Maria Favero-
Autor(es): dc.creatorMartins, Manoela Domingues-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T22:08:24Z-
Data de disponibilização: dc.date.available2025-08-21T22:08:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/1354750X.2023.2298182-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298104-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298104-
Descrição: dc.descriptionBackground and Objectives: In order to detect genetic damage, different methods have been developed, such as micronuclei and comet assay. The comet assay presents some advantages when compared to the other aforementioned methods, including wide versatility, as any eukaryotic cell can be evaluated at an individual cellular level. In this context, the aim of this systematic review was designed to help further elucidate the following question: is the comet assay a suitable biomarker of in vivo oral carcinogenesis? Material and Methods: The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Full manuscripts from 18 studies were carefully selected in this setting. Results: A total of 15 studies demonstrated positive findings for genotoxicity in peripheral blood or oral cells in patients with pre-malignant lesions or oral cancer. In the quality assessment of studies, 1 was classified as Strong, 5 were considered as Moderate, and 12 were classified as Weak. Conclusion: In summary, the comet assay can be a useful biomarker for oral carcinogenesis. However, further studies with more strict parameters are suggested (with less uncontrolled confounders) in order to increase findings reliability for diagnosis of oral potentially malignant lesions.-
Descrição: dc.descriptionDepartment of Biosciences Institute of Health and Society Federal University of São Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmacy Federal University of Ouro Preto UFOP, MG-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionDepartment of Oral Pathology School of Dentistry Federal University of Rio Grande do Sul UFRS, RS-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School Sao Paulo State University UNESP, SP-
Formato: dc.format692-702-
Idioma: dc.languageen-
Relação: dc.relationBiomarkers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcarcinogenesis-
Palavras-chave: dc.subjectcomet assay-
Palavras-chave: dc.subjectoral mucosa cancer-
Título: dc.titleComet assay as a suitable biomarker for in vivo oral carcinogenesis: a systematic review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.