Investigating tributyltin's toxic effects: Intestinal barrier and neuroenteric disruption in rat's jejunum

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorOliveira, I. C.C.S.-
Autor(es): dc.creatorMarinsek, G. P.-
Autor(es): dc.creatorGonçalves, A. R.N.-
Autor(es): dc.creatorLopes, B. S.-
Autor(es): dc.creatorCorreia, L. V.B.-
Autor(es): dc.creatorDa Silva, R. C.B.-
Autor(es): dc.creatorCastro, I. B.-
Autor(es): dc.creatorMari, R. B.-
Data de aceite: dc.date.accessioned2025-08-21T16:22:12Z-
Data de disponibilização: dc.date.available2025-08-21T16:22:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.neuro.2024.10.004-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298063-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298063-
Descrição: dc.descriptionThe expansion of economic activities in coastal areas has significantly increased chemical contamination, leading to major environmental challenges. Contaminants enter the human body through the food chain, particularly via seafood and water consumption, triggering biomagnification and bioaccumulation processes. The gastrointestinal tract (GIT) acts as a selective barrier, protecting against chemical pollutants and maintaining homeostasis through a complex network of cells and immune responses. This study assessed impact of tributyltin (TBT), a highly toxic organometallic compound used in antifouling coatings for ships, on the GIT and myenteric neural plasticity in young rats. TBT exposure leads to histopathological changes, including epithelial detachment and inflammatory foci, especially at lower environmental doses. The study found that TBT causes significant reductions in villi height, increases in goblet cells and intraepithelial lymphocytes, and disrupts the myenteric plexus, with higher densities of extraganglionic neurons in exposed animals.-
Descrição: dc.descriptionUNESP São Paulo State University Institute of Biosciences Paulista Coast Campus (CLP), SP-
Descrição: dc.descriptionUNIFESP Federal University of São Paulo Institute of Health and Society Baixada Santista Campus, SP-
Descrição: dc.descriptionUNIFESP Federal University of São Paulo Institute of Marine Science Baixada Santista Campus, SP-
Descrição: dc.descriptionUNESP São Paulo State University Institute of Biosciences Paulista Coast Campus (CLP), SP-
Formato: dc.format208-215-
Idioma: dc.languageen-
Relação: dc.relationNeuroToxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifouling-
Palavras-chave: dc.subjectExtraganglionic neurons-
Palavras-chave: dc.subjectGut defense-
Palavras-chave: dc.subjectMorphophysiology-
Título: dc.titleInvestigating tributyltin's toxic effects: Intestinal barrier and neuroenteric disruption in rat's jejunum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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