Identification of biological pathways and putative candidate genes for residual feed intake in a tropically adapted beef cattle breed by plasma proteome analysis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorAnimal Science Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Georgia-
Autor(es): dc.contributorUniversity of Connecticut-
Autor(es): dc.contributorAngus Genetics Inc-
Autor(es): dc.creatorMalheiros, Jessica M.-
Autor(es): dc.creatorReolon, Henrique G.-
Autor(es): dc.creatorBosquini, Bruna G.-
Autor(es): dc.creatorBaldi, Fernando-
Autor(es): dc.creatorLourenco, Daniela-
Autor(es): dc.creatorFragomeni, Breno O.-
Autor(es): dc.creatorSilva, Rafael M.O.-
Autor(es): dc.creatorPaz, Claudia C.P.-
Autor(es): dc.creatorStafuzza, Nedenia B.-
Data de aceite: dc.date.accessioned2025-08-21T16:57:46Z-
Data de disponibilização: dc.date.available2025-08-21T16:57:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-02-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jprot.2024.105361-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/298043-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/298043-
Descrição: dc.descriptionThis study identified potential biomarkers for feed efficiency by blood plasma proteome analysis of a tropically adapted beef cattle breed. Two experimental groups were selected based on residual feed intake (RFI). The proteome was investigated by LC-MS/MS in a data-dependent acquisition mode. After quality control, 123 differentially abundant proteins (DAPs) were identified between the two experimental groups. Among DAPs with the highest absolute log-fold change values, the PRDM2, KRT5, UGGT1, DENND5B, B2M, SLC44A2, SLC7A2, PTPRC, and FETUB were highlighted as potential biomarkers because of their functions that may contribute to RFI. Furthermore, functional enrichment analysis revealed several biological processes, molecular functions and pathways that contributes to RFI, such as cell signaling, cellular responses to stimuli, immune system, calcium, hormones, metabolism and functions of proteins, lipids and carbohydrates. Protein-protein interaction analysis identified 32 and 11 DAPs as important nodes based on their interactions in the high- and low-RFI groups, respectively. This study represents the first comprehensive profiling of the blood plasma proteome of a tropically adapted beef cattle breed and provides valuable insights into the potential roles of these DAPs in key biological processes and pathways, contributing to our understanding of the mechanisms underlying feed efficiency in tropically adapted beef cattle. Significance: LC-MS/MS analysis was performed to investigate changes in the blood plasma proteome associated with residual feed intake (RFI) in a tropically adapted beef cattle breed (Bos taurus taurus). Some putative biomarkers were identified to distinguish the high-RFI to low-RFI animals, based on their log-fold change value or on their protein-protein interaction network, which provide helpful sources in developing novel selection strategies for breeding programs. Our findings also revealed valuable insights into the metabolic pathways and biological processes that contribute to RFI in beef cattle, such as those closely linked to cell signaling, cellular responses to stimuli, immune system, calcium, hormones, metabolism and functions of proteins, lipids and carbohydrates.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBeef Cattle Research Center Animal Science Institute, SP-
Descrição: dc.descriptionDepartment of Animal Science School of Agricultural and Veterinary Sciences São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Animal and Dairy Science University of Georgia-
Descrição: dc.descriptionDepartment of Animal Science University of Connecticut-
Descrição: dc.descriptionAngus Genetics Inc-
Descrição: dc.descriptionSustainable Livestock Research Center Animal Science Institute, SP-
Descrição: dc.descriptionDepartment of Animal Science School of Agricultural and Veterinary Sciences São Paulo State University, SP-
Descrição: dc.descriptionCNPq: 138213/2020-8-
Descrição: dc.descriptionFAPESP: 2018/19216–7-
Descrição: dc.descriptionFAPESP: 2019/10438-0-
Descrição: dc.descriptionFAPESP: 2019/17251-2-
Descrição: dc.descriptionFAPESP: 2020/03699-9-
Descrição: dc.descriptionFAPESP: 2022/12669-1-
Descrição: dc.descriptionCNPq: 302914/2022-6-
Idioma: dc.languageen-
Relação: dc.relationJournal of Proteomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBos taurus taurus-
Palavras-chave: dc.subjectCaracu-
Palavras-chave: dc.subjectfeed efficiency-
Palavras-chave: dc.subjectliquid chromatography-tandem mass spectrometry-
Palavras-chave: dc.subjectpotential biomarkers-
Palavras-chave: dc.subjectprotein-protein interaction-
Título: dc.titleIdentification of biological pathways and putative candidate genes for residual feed intake in a tropically adapted beef cattle breed by plasma proteome analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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