Insight into the role of copper-based materials against the coronaviruses MHV-3, a model for SARS-CoV-2, during the COVID-19 pandemic

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorPhysicochimie des Électrolytes et Nanosystèmes InterfaciauX (PHENIX)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorJacinto, Gislaine S.-
Autor(es): dc.creatorDias, Leonardo F. G.-
Autor(es): dc.creatorTsukamoto, Junko-
Autor(es): dc.creatorLisboa-Filho, Paulo N.-
Autor(es): dc.creatorSouza, Marina T.-
Autor(es): dc.creatorde Moraes, Ana Paula-
Autor(es): dc.creatorArns, Clarice W.-
Data de aceite: dc.date.accessioned2025-08-21T20:50:10Z-
Data de disponibilização: dc.date.available2025-08-21T20:50:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10534-024-00585-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297951-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297951-
Descrição: dc.descriptionCoating high-touch surfaces with inorganic agents, such as metals, appears to be a promising long-term disinfection strategy. However, there is a lack of studies exploring the effectiveness of copper-based products against viruses. In this study, we evaluated the cytotoxicity and virucidal effectiveness of products and materials containing copper against mouse hepatitis virus (MHV-3), a surrogate model for SARS-CoV-2. The results demonstrate that pure CuO and Cu possess activity against the enveloped virus at very low concentrations, ranging from 0.001 to 0.1% (w/v). A greater virucidal efficacy of CuO was found for nanoparticles, which showed activity even against viruses that are more resistant to disinfection such as feline calicivirus (FCV). Most of the evaluated products, with concentrations of Cu or CuO between 0.003 and 15% (w/v), were effective against MHV-3. Cryomicroscopy images of an MHV-3 sample exposed to a CuO-containing surface showed extensive damage to the viral capsid, presumably due to the direct or indirect action of copper ions.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Virology and Applied Biotechnology Department of Genetics Evolution Microbiology and Immunology Institute of Biology Universidade Estadual de Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionSorbonne Université CNRS Physicochimie des Électrolytes et Nanosystèmes InterfaciauX (PHENIX)-
Descrição: dc.descriptionDepartment of Physics and Meteorology School of Sciences UNESP - São Paulo State University, São Paulo-
Descrição: dc.descriptionCeRTEV – Center for Research Technology and Education in Vitreous Materials Vitreous Materials Laboratory Department of Materials Engineering Federal University of São Carlos, SP-
Descrição: dc.descriptionDepartment of Physics and Meteorology School of Sciences UNESP - São Paulo State University, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format923-941-
Idioma: dc.languageen-
Relação: dc.relationBioMetals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCopper-
Palavras-chave: dc.subjectMHV-3-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectSelf-disinfection-
Palavras-chave: dc.subjectVirucidal activity-
Título: dc.titleInsight into the role of copper-based materials against the coronaviruses MHV-3, a model for SARS-CoV-2, during the COVID-19 pandemic-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.