Functional lateralization in the medial prefrontal cortex control of contextual conditioned emotional responses in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGomes-de-Souza, Lucas-
Autor(es): dc.creatorBusnardo, Cristiane-
Autor(es): dc.creatorSantos, Adrielly-
Autor(es): dc.creatorPaz, Higor S.-
Autor(es): dc.creatorResstel, Leonardo B.-
Autor(es): dc.creatorPlaneta, Cleopatra S.-
Autor(es): dc.creatorNunes-de-Souza, Ricardo L.-
Autor(es): dc.creatorCrestani, Carlos C.-
Data de aceite: dc.date.accessioned2025-08-21T22:38:26Z-
Data de disponibilização: dc.date.available2025-08-21T22:38:26Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2024.111015-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297900-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297900-
Descrição: dc.descriptionA functional lateralization has been reported in control of emotional responses by the medial prefrontal cortex (mPFC). However, a hemisphere asymmetry in involvement of the mPFC in expression of fear conditioning responses has never been reported. Therefore, we investigated whether control by mPFC of freezing and cardiovascular responses during re-exposure to an aversively conditioned context is lateralized. For this, rats had guide cannulas directed to the mPFC implanted bilaterally or unilaterally in the right or left hemispheres. Vehicle or the non-selective synaptic inhibitor CoCl2 was microinjected into the mPFC 10 min before re-exposure to a chamber where the animals had previously received footshocks. A catheter was implanted into the femoral artery before the fear retrieval test for cardiovascular recordings. We observed that bilateral microinjection of CoCl2 into the mPFC reduced both the freezing behavior (enhancing locomotion and rearing) and arterial pressure and heart rate increases during re-exposure to the aversively conditioned context. Unilateral microinjection of CoCl2 into the right hemisphere of the mPFC also decreased the freezing behavior (enhancing locomotion and rearing), but without affecting the cardiovascular changes. Conversely, unilateral synaptic inhibition in the left mPFC did not affect either behavioral or cardiovascular responses during fear retrieval test. Taken together, these results suggest that the right hemisphere of the mPFC is necessary and sufficient for expression of freezing behavior to contextual fear conditioning. However, the control of cardiovascular responses and freezing behavior during fear retrieval test is somehow dissociated in the mPFC, being the former bilaterally processed.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionDepartment of Pharmacology School of Medicine of Ribeirão Preto University of São Paulo, SP-
Descrição: dc.descriptionLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionFAPESP: 2022/06260–3-
Descrição: dc.descriptionCNPq: 431339/2018–0-
Idioma: dc.languageen-
Relação: dc.relationProgress in Neuro-Psychopharmacology and Biological Psychiatry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnxiety-
Palavras-chave: dc.subjectCardiovascular function-
Palavras-chave: dc.subjectCerebral cortex-
Palavras-chave: dc.subjectFreezing-
Palavras-chave: dc.subjectHemisphere asymmetry-
Título: dc.titleFunctional lateralization in the medial prefrontal cortex control of contextual conditioned emotional responses in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.