Metronidazole-laden silk fibroin methacrylated scaffolds for managing periapical lesions

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.creatorSilverberg, Ashley-
Autor(es): dc.creatorCardoso, Lais M.-
Autor(es): dc.creatorde Carvalho, Ana Beatriz G.-
Autor(es): dc.creatordos Reis-Prado, Alexandre H.-
Autor(es): dc.creatorFenno, J. Christopher-
Autor(es): dc.creatorDal-Fabbro, Renan-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2025-08-21T21:21:07Z-
Data de disponibilização: dc.date.available2025-08-21T21:21:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10266-024-01023-y-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297895-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297895-
Descrição: dc.descriptionThis study aimed to develop and characterize silk fibroin methacrylated/SilkMA electrospun scaffolds associated with metronidazole/MET to control infection in root-end resected periapical lesions while supporting bone regeneration. SilkMA-based formulations (10% w/v) incorporating MET (0—control; 5, 15, or 30% w/w) were electrospun into fibrous scaffolds and photocrosslinked. Scaffolds’ morphology, chemical composition, swelling/degradation profiles, mechanical properties, cytocompatibility with alveolar bone-derived mesenchymal stem cells/aBMSCs and stem cells from apical papilla/SCAPs, anti-inflammatory potential, and antibacterial efficacy (direct contact assay against Aggregatibacter actinomycetemcomitans/Aa and Fusobacterium nucleatum/Fn; Aa biofilm model) were assessed. Statistical analysis was conducted using a significance level of 5%. Morphological analysis revealed that MET content influenced fiber diameters post-crosslinking, while the chemical composition analysis confirmed MET integration within the scaffolds. 30%MET-laden scaffolds demonstrated reduced swelling capacity compared to SilkMA/control scaffolds, while complete degradation was observed after 42 days for the formulated scaffolds. Mechanical testing indicated enhanced stiffness and tensile strength in 30%MET-laden scaffolds compared to SilkMA/control (p < 0.05). Cytocompatibility evaluations showed non-cytotoxic effects across all formulations for aBMSCs and SCAPs. Anti-inflammatory assays demonstrated decreased pro-inflammatory cytokine interleukin-6 synthesis by aBMSCs treated with SilkMA + MET30% and Escherichia coli LPS, comparable to negative control (p > 0.05). Antibacterial efficacy assays revealed significant inhibition of Aa and Fn, with 30%MET-laden scaffolds demonstrating biofilm inhibition against Aa (p < 0.05). These findings underscore the potential of SilkMA scaffolds laden with MET as a promising strategy for managing periapical lesions, offering enhanced structural support, antimicrobial properties, and biocompatibility crucial for effective tissue regeneration and infection control after endodontic surgery.-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics University of Michigan School of Dentistry, 1011 N. University Avenue, Room 2303-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (UNESP) Araraquara School of Dentistry, 1680 Humaita Street, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (UNESP) São Jose Dos Campos School of Dentistry, 777 Eng. Francisco Jose Longo Avenue, SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Minas Gerais Federal University (UFMG) School of Dentistry, 688 Prof. Moacir Gomes de Freitas Street, MG-
Descrição: dc.descriptionDepartment of Biologic and Materials Sciences & amp; Prosthodontics University of Michigan School of Dentistry, 1011 N. University Avenue-
Descrição: dc.descriptionDepartment of Biomedical Engineering College of Engineering University of Michigan-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (UNESP) Araraquara School of Dentistry, 1680 Humaita Street, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (UNESP) São Jose Dos Campos School of Dentistry, 777 Eng. Francisco Jose Longo Avenue, SP-
Idioma: dc.languageen-
Relação: dc.relationOdontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApical periodontitis-
Palavras-chave: dc.subjectApicoectomy-
Palavras-chave: dc.subjectMetronidazole-
Palavras-chave: dc.subjectSilk-
Palavras-chave: dc.subjectTissue scaffolds-
Título: dc.titleMetronidazole-laden silk fibroin methacrylated scaffolds for managing periapical lesions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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