Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Sagrado Coracao USC-
Autor(es): dc.creatorHoshino, Roberto Alameda-
Autor(es): dc.creatorDelfino, Mateus Machado-
Autor(es): dc.creatorSilva, Guilherme Ferreira da-
Autor(es): dc.creatorGuerreiro-Tanomaru, Juliane Maria-
Autor(es): dc.creatorTanomaru-Filho, Mario-
Autor(es): dc.creatorSasso-Cerri, Estela-
Autor(es): dc.creatorCerri, Paulo Sergio-
Data de aceite: dc.date.accessioned2025-08-21T22:29:00Z-
Data de disponibilização: dc.date.available2025-08-21T22:29:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.5395/rde.2021.46.e4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297890-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297890-
Descrição: dc.descriptionObjectives: This study evaluated the biocompatibility and bioactive potential of NeoMTA Plus mixed as a root canal sealer in comparison with MTA Fillapex. Materials and Methods: Polyethylene tubes filled with NeoMTA Plus ( n = 20), MTA Fillapex ( n = 20), or nothing (control group, CG; n = 20) were inserted into the connective tissue in the dorsal subcutaneous layer of rats. After 7, 15, 30 and 60 days, the specimens were processed for paraffin embedding. The capsule thickness, collagen content, and number of inflammatory cells (ICs) and interleukin-6 (IL-6) immunolabeled cells were measured. von Kossa-positive structures were evaluated and unstained sections were analyzed under polarized light. Two-way analysis of variance was performed, followed by the post hoc Tukey test (p <= 0.05). Results: At 7 days, the capsules around NeoMTA Plus and MTA Fillapex had more ICs and IL-6-immunostained cells than the CG. However, at 60 days, there was no significant difference in the IC number between NeoMTA Plus and the CG ( p = 0.1137) or the MTA Fillapex group ( p = 0.4062), although a greater number of IL-6-immunostained cells was observed in the MTA Fillapex group (p = 0.0353). From 7 to 60 days, the capsule thickness of the NeoMTA Plus and MTA Fillapex specimens significantly decreased, concomitantly with an increase in the collagen content. The capsules around root canal sealers showed positivity to the von Kossa stain and birefringent structures. Conclusions: The NeoMTA Plus root canal sealer is biocompatible and exhibits bioactive potential.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Dent, Dept Restorat Dent, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Sagrado Coracao USC, Sch Dent, Prorectory Res & Postgrad, Bauru, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Dent, Lab Histol & Embryol, Dept Morphol Genet Orthodont & Pediat Dent, Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Dent, Dept Restorat Dent, Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Sch Dent, Lab Histol & Embryol, Dept Morphol Genet Orthodont & Pediat Dent, Araraquara, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2016/09264-9-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherKorean Acad Conservative Dentistry-
Relação: dc.relationRestorative Dentistry And Endodontics-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBioactive potential-
Palavras-chave: dc.subjectBiocompatibility-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectInflammatory reaction-
Palavras-chave: dc.subjectInterleukin-6-
Título: dc.titleBiocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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