Amphotericin B-loaded natural latex dressing for treating Candida albicans wound infections using Galleria mellonella model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation (TIBI)-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.contributorFundação Educacional do Município de Assis (FEMA)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorUniversity Center of the Integrated Faculties of Ourinhos (UNIFIO)-
Autor(es): dc.contributorUniversity of Veterinary Medicine and Pharmacy in Košice-
Autor(es): dc.contributorUniversity Hospital Ghent-
Autor(es): dc.contributorFederal University of Triangulo Mineiro (UFTM)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorScience and Technology of Minas Gerais-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatordos Reis, Camila Eugênia-
Autor(es): dc.creatorde Souza, Silvia Maria Batista-
Autor(es): dc.creatorPegorin Brasil, Giovana Sant'Ana-
Autor(es): dc.creatorScontri, Mateus-
Autor(es): dc.creatorKawakita, Satoru-
Autor(es): dc.creatorCarvalho, Bruna Gregatti-
Autor(es): dc.creatorBebber, Camila Calderan-
Autor(es): dc.creatorSu, Yanjin-
Autor(es): dc.creatorde Sousa Abreu, Ana Paula-
Autor(es): dc.creatorMecwan, Marvin M-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorFusco Almeida, Ana Marisa-
Autor(es): dc.creatorMendes Giannini, Maria José Soares-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorBosculo, Maria Rachel Melo-
Autor(es): dc.creatorGemeinder, José Lúcio Pádua-
Autor(es): dc.creatorde Almeida, Breno Fernando Martins-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorFarhadi, Neda-
Autor(es): dc.creatorMonirizad, Mahsa-
Autor(es): dc.creatorKhorsandi, Danial-
Autor(es): dc.creatorNguyen, Huu Tuan-
Autor(es): dc.creatorGomez, Alejandro-
Autor(es): dc.creatorTirpáková, Zuzana-
Autor(es): dc.creatorPeirsman, Arne-
Autor(es): dc.creatorda Silva Sasaki, Josana Carla-
Autor(es): dc.creatorHe, Siqi-
Autor(es): dc.creatorForster, Samuel-
Autor(es): dc.creatorBurd, Betina Sayeg-
Autor(es): dc.creatorDokmeci, Mehmet Remzi-
Autor(es): dc.creatorTerra-Garcia, Maíra-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorde Mendonça, Ricardo José-
Autor(es): dc.creatorCardoso, Marcos Roberto-
Autor(es): dc.creatordos Santos, Lindomar Soares-
Autor(es): dc.creatorSilva, Gláucio Ribeiro-
Autor(es): dc.creatorBarros, Natan Roberto-
Autor(es): dc.creatorJucaud, Vadim-
Autor(es): dc.creatorLi, Bingbing-
Data de aceite: dc.date.accessioned2025-08-21T19:08:57Z-
Data de disponibilização: dc.date.available2025-08-21T19:08:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jconrel.2023.12.010-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297872-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297872-
Descrição: dc.descriptionAmphotericin B (AmB) is the gold standard for antifungal drugs. However, AmB systemic administration is restricted because of its side effects. Here, we report AmB loaded in natural rubber latex (NRL), a sustained delivery system with low toxicity, which stimulates angiogenesis, cell adhesion and accelerates wound healing. Physicochemical characterizations showed that AmB did not bind chemically to the polymeric matrix. Electronic and topographical images showed small crystalline aggregates from AmB crystals on the polymer surface. About 56.6% of AmB was released by the NRL in 120 h. However, 33.6% of this antifungal was delivered in the first 24 h due to the presence of AmB on the polymer surface. The biomaterial's excellent hemo- and cytocompatibility with erythrocytes and human dermal fibroblasts (HDF) confirmed its safety for dermal wound application. Antifungal assay against Candida albicans showed that AmB-NRL presented a dose-dependent behavior with an inhibition halo of 30.0 ± 1.0 mm. Galleria mellonella was employed as an in vivo model for C. albicans infection. Survival rates of 60% were observed following the injection of AmB (0.5 mg.mL−1) in G. mellonella larvae infected by C. albicans. Likewise, AmB-NRL (0.5 mg.mL−1) presented survival rates of 40%, inferring antifungal activity against fungus. Thus, NRL adequately acts as an AmB-sustained release matrix, which is an exciting approach, since this antifungal is toxic at high concentrations. Our findings suggest that AmB-NRL is an efficient, safe, and reasonably priced ($0.15) dressing for the treatment of cutaneous fungal infections.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic Blvd-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionFundação Educacional do Município de Assis (FEMA), 1200 Getulio Vargas Avenue, SP-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) Department of Materials and Bioprocesses Engineering School of Chemical Engineering, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Clinical Analysis School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences, SP-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionUniversity Center of the Integrated Faculties of Ourinhos (UNIFIO), Km 338, BR-153, SP-
Descrição: dc.descriptionUniversity of Veterinary Medicine and Pharmacy in Košice, Komenského 73-
Descrição: dc.descriptionPlastic Reconstructive and Aesthetic Surgery University Hospital Ghent-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), Minas Gerais-
Descrição: dc.descriptionSão Carlos Institute of Physics University of São Paulo, PO Box 369, SP-
Descrição: dc.descriptionFaculty of Philosophy Sciences and Languages of Ribeirão Preto Universidade de São Paulo University (USP), 3900 Bandeirantes Avenue, 14, SP-
Descrição: dc.descriptionFederal Institute of Education Science and Technology of Minas Gerais, s/n São Luiz Gonzaga Street, MG-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Clinical Analysis School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences, SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2017/19603–8-
Descrição: dc.descriptionFAPESP: 2018/07342–8-
Descrição: dc.descriptionFAPESP: 2021/09207–3-
Descrição: dc.descriptionCNPq: 317203/2021–5-
Descrição: dc.descriptionCNPq: 470261/2012–9-
Formato: dc.format744-758-
Idioma: dc.languageen-
Relação: dc.relationJournal of Controlled Release-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmphotericin B-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectDressing-
Palavras-chave: dc.subjectFungal skin infections-
Palavras-chave: dc.subjectNatural polymer-
Título: dc.titleAmphotericin B-loaded natural latex dressing for treating Candida albicans wound infections using Galleria mellonella model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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