Helium Cold Atmospheric Plasma Causes Morphological and Biochemical Alterations in Candida albicans Cells

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLeibniz Institute for Plasma Science and Technology-
Autor(es): dc.creatorRovetta-Nogueira, Sabrina de Moura-
Autor(es): dc.creatorBorges, Aline Chiodi-
Autor(es): dc.creatorOliveira Filho, Maurício de-
Autor(es): dc.creatorNishime, Thalita Mayumi Castaldelli-
Autor(es): dc.creatorHein, Luis Rogerio de Oliveira-
Autor(es): dc.creatorKostov, Konstantin Georgiev-
Autor(es): dc.creatorKoga-Ito, Cristiane Yumi-
Data de aceite: dc.date.accessioned2025-08-21T19:11:31Z-
Data de disponibilização: dc.date.available2025-08-21T19:11:31Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules28237919-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297868-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297868-
Descrição: dc.description(1) Background: Previous studies reported the promising inhibitory effect of cold atmospheric plasma (CAP) on Candida albicans. However, the exact mechanisms of CAP’s action on the fungal cell are still poorly understood. This study aims to elucidate the CAP effect on C. albicans cell wall, by evaluating the alterations on its structure and biochemical composition; (2) Methods: C. albicans cells treated with Helium-CAP were analyzed by atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR) in order to detect morphological, topographic and biochemical changes in the fungal cell wall. Cells treated with caspofungin were also analyzed for comparative purposes; (3) Results: Expressive morphological and topographic changes, such as increased roughness and shape modification, were observed in the cells after CAP exposure. The alterations detected were similar to those observed after the treatment with caspofungin. The main biochemical changes occurred in polysaccharides content, and an overall decrease in glucans and an increase in chitin synthesis were detected; (4) Conclusions: Helium-CAP caused morphological and topographic alterations in C. albicans cells and affected the cell wall polysaccharide content.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionOral Biopathology Graduate Program Department of Environment Engineering São José dos Campos Institute of Science & Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Materials and Technology Guaratinguetá Faculty of Engineering and Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLeibniz Institute for Plasma Science and Technology-
Descrição: dc.descriptionDepartment of Physics Guaratinguetá Faculty of Engineering São Paulo State University (UNESP), SP-
Descrição: dc.descriptionOral Biopathology Graduate Program Department of Environment Engineering São José dos Campos Institute of Science & Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Materials and Technology Guaratinguetá Faculty of Engineering and Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physics Guaratinguetá Faculty of Engineering São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: 309762/2021-9-
Descrição: dc.descriptionCNPq: 310608/2021-0-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAFM-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCaspofungin-
Palavras-chave: dc.subjectchitin-
Palavras-chave: dc.subjectcold atmospheric plasma-
Palavras-chave: dc.subjectFTIR-
Palavras-chave: dc.subjectglucans-
Título: dc.titleHelium Cold Atmospheric Plasma Causes Morphological and Biochemical Alterations in Candida albicans Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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