Sustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of South Australia-
Autor(es): dc.creatorCremasco, Gabriela-
Autor(es): dc.creatorSutton, Adam T.-
Autor(es): dc.creatorFunari, Cristiano S.-
Autor(es): dc.creatorArrua, Dario R.-
Autor(es): dc.creatorDussan, Kelly J.-
Autor(es): dc.creatorHilder, Emily F.-
Autor(es): dc.creatorBolzani, Vanderlan S.-
Autor(es): dc.creatorRinaldo, Daniel-
Data de aceite: dc.date.accessioned2025-08-21T21:21:53Z-
Data de disponibilização: dc.date.available2025-08-21T21:21:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules29133034-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297816-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297816-
Descrição: dc.descriptionAlmond trees are the most cultivated nut tree in the world. The production of almonds generates large amounts of by-products, much of which goes unused. Herein, this study aimed to develop a green chemistry approach to identify and extract potentially valuable compounds from almond by-products. Initially, a screening was performed with 10 different Natural Deep Eutectic Solvents (NADESs). The mixture lactic acid/glycerol, with a molar ratio 1:1 (1:50 plant material to NADES (w/v) with 20% v/v of water) was identified as the best extraction solvent for catechin, caffeoylquinic acid, and condensed tannins in almond hulls. Subsequently, a method was optimized by a Design of Experiment (DoE) protocol using a miniaturized extraction technique, Microwave-Assisted Extraction (MAE), in conjunction with the chosen NADESs. The optimal conditions were found to be 70 °C with 15 min irradiation time. The optimal extraction conditions determined by the DoE were confirmed experimentally and compared to methods already established in the literature. With these conditions, the extraction of metabolites was 2.4 times higher, according to the increase in total peak area, than the established literature methods used. Additionally, by applying the multiparameter Analytical Greenness Metric (AGREE) and Green Analytical Process Index (GAPI) metrics, it was possible to conclude that the developed method was greener than the established literature methods as it includes various principles of green analytical chemistry.-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), R. Prof. Francisco Degni 55, SP-
Descrição: dc.descriptionFuture Industries Institute Mawson Lakes Campus University of South Australia-
Descrição: dc.descriptionGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP), Av. Universitária, nº 3780-Altos do Paraíso, SP-
Descrição: dc.descriptionGreen Biotech Network School of Sciences São Paulo State University (UNESP), Av. Eng. Luiz Edmundo Carrijo Coube 14-01, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), R. Prof. Francisco Degni 55, SP-
Descrição: dc.descriptionGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP), Av. Universitária, nº 3780-Altos do Paraíso, SP-
Descrição: dc.descriptionGreen Biotech Network School of Sciences São Paulo State University (UNESP), Av. Eng. Luiz Edmundo Carrijo Coube 14-01, SP-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdesign of experiments-
Palavras-chave: dc.subjectgreen chemistry-
Palavras-chave: dc.subjectMicrowave-Assisted Extraction-
Palavras-chave: dc.subjectNADESs-
Palavras-chave: dc.subjectPrunus dulcis-
Título: dc.titleSustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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