Genetic polymorphisms on temporomandibular disorders: Network meta-analysis

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Autor(es): dc.contributorAlfenas Federal University (Unifal-MG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorAlmeida, Daniel Augusto de Faria-
Autor(es): dc.creatorBrant, Camila Freire-
Autor(es): dc.creatorda Costa Siqueira, Letícia-
Autor(es): dc.creatorSoares, Lélio Fernando Ferreira-
Autor(es): dc.creatorOliveira, Jovânia Alves-
Autor(es): dc.creatorde Oliveira, Daniela Silva Barroso-
Autor(es): dc.creatorPigossi, Suzane Cristina-
Autor(es): dc.creatorSoares, Carlos José-
Data de aceite: dc.date.accessioned2025-08-21T15:40:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:40:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2025.106235-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297811-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297811-
Descrição: dc.descriptionObjective: The aim of this systematic review and network meta-analysis (NMA) is to compare and rank the effects of different genetic polymorphisms on the susceptibility of temporomandibular disorders (TMDs) occurrence. Design: The central question formulated was: “Are genetic polymorphisms involved in the etiology of TMDs?” Following PROSPERO registration (CRD42024507886), electronic searches were conducted in five databases for publications up to November 2024. Results: Sixty-three studies were included in the systematic review and 7 composed the NMA. The qualitative analysis summarized the association between 120 genes (and 206 polymorphisms) and TMDs. Thirty-two polymorphisms (in 24 genes) were linked to overall TMDs, while 22 polymorphisms (in 22 genes) with degenerative bone changes in the temporomandibular joint (TMJ). Additionally, 17 polymorphisms were identified in cases of painful chronic TMD, while 12 polymorphisms in intra-articular disorders. These polymorphisms were in genes related to neurotransmission (COMT, ADRB2, DRD2, ANKK1, SLC6A4 and HTR2A), inflammatory mediators (TNFα, IL10 and MMP1), sex hormones (ESR1and ESRRB), oxidative stress (GSTM1) and bone metabolism (VDR). A protective effect for myalgia occurrence with the COMT_rs165774 polymorphism compared to the wild-type genotype was found in the pairwise meta-analysis (AG genotype: OR: 0.33; 95 %CI: 0.14, 0.76; p < 0.01 and GG genotype: OR: 0.32; 95 %CI: 0.14, 0.74; p < 0.01) and this polymorphism showed the highest probability of being associated with the myalgia (97 %) and arthralgia (93 %) conditions. Conclusions: Genetic polymorphisms in genes related to neurotransmission, inflammatory response, and sex hormones seem to be risk factors related to the TMDs pathogenesis.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionSchool of Dentistry Alfenas Federal University (Unifal-MG), Minas Gerais-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State of University (FOAR/UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Periodontology and Implantodontology School of Dentistry Federal University of Uberlândia - UFU, Minas Gerais-
Descrição: dc.descriptionDepartment of Operative Dentistry and Dental Materials School of Dentistry Federal University of Uberlândia - UFU, Minas Gerais-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State of University (FOAR/UNESP), São Paulo-
Descrição: dc.descriptionFAPEMIG: RED-0020423-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectPolymorphism-
Palavras-chave: dc.subjectSingle nucleotide polymorphisms-
Palavras-chave: dc.subjectTemporomandibular joint disorders-
Título: dc.titleGenetic polymorphisms on temporomandibular disorders: Network meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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