Synthesis and Evaluation of Porous Nanosynt Block (FGM®) as Synthetic Bone Substitute for Bone Tissue Engineering

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorSanta Catarina State University (UDESC)-
Autor(es): dc.creatorSilva dos Santos, Jaqueline-
Autor(es): dc.creatorGonçales Souza, Ana Carla-
Autor(es): dc.creatorFantasia, Ricardo-
Autor(es): dc.creatorCury Cecato, Rafael-
Autor(es): dc.creatorDias, Gabriela Aline-
Autor(es): dc.creatorde Souza Batista, Victor Eduardo-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorRamos Verri, Fellippo-
Data de aceite: dc.date.accessioned2025-08-21T20:33:50Z-
Data de disponibilização: dc.date.available2025-08-21T20:33:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/coatings15030297-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297810-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297810-
Descrição: dc.descriptionSynthetic bone substitutes based on hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) are widely used in regenerative dentistry due to their favorable biocompatibility and osteoconductive properties. This study aimed to evaluate, through laboratory-based analyses, the porosity and surface characteristics of the Nanosynt Block (FGM Dental Group®) for bone regeneration applications. The Nanosynt Block, consisting of 60% HA and 40% β-TCP, was analyzed using scanning electron microscopy (SEM) for surface morphology characterization, micro-computed tomography (Micro-CT) for internal structure evaluation, and mercury intrusion porosimetry for porosity assessment. SEM imaging followed the ASTM E1829-02 standard, while Micro-CT and porosimetry provided detailed quantitative data. SEM analysis revealed a homogeneous pore distribution on the surface. Micro-CT indicated high structural stability and consistent volumetric porosity, ranging from 73.27% to 77.08%. Porosimetry indicated a total porosity of 94.9%, with a median pore diameter of 799 nm, characteristics suitable for promoting cellular adhesion and fluid infiltration. The structural and morphological properties of the Nanosynt Block highlight its potential to support initial bone formation and mechanical stability in clinical applications. These findings provide a robust basis for subsequent in vivo investigations to validate its clinical efficacy.-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University “Júlio de Mesquita Filho”, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araçatuba Dental School São Paulo State University “Júlio de Mesquita Filho”, SP-
Descrição: dc.descriptionImplant Dentistry Center for Education and Research on Dental Implants (CEPID) Department of Dentistry Federal University of Santa Catarina (UFSC), SC-
Descrição: dc.descriptionDepartment of Chemistry Santa Catarina State University (UDESC), SC-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University “Júlio de Mesquita Filho”, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araçatuba Dental School São Paulo State University “Júlio de Mesquita Filho”, SP-
Idioma: dc.languageen-
Relação: dc.relationCoatings-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone substitute-
Palavras-chave: dc.subjecthydroxyapatites-
Palavras-chave: dc.subjectporosity-
Título: dc.titleSynthesis and Evaluation of Porous Nanosynt Block (FGM®) as Synthetic Bone Substitute for Bone Tissue Engineering-
Tipo de arquivo: dc.typelivro digital-
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