Evaluation of hypoxia-inducible factor-1 and 2 alpha inhibitory compounds in the oral cavity and pharyngeal cancer

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Autor(es): dc.contributorFaculty of Medicine of São José do Rio Preto/SP – FAMERP-
Autor(es): dc.contributorFAMERP-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTedeschi, Bianca Barbério Bogdan-
Autor(es): dc.creatorHenrique, Tiago-
Autor(es): dc.creatorVila, Ana Paula Simedan-
Autor(es): dc.creatorRodrigues, Gabriela Helena-
Autor(es): dc.creatorKawasaki-Oyama, Rosa Sayoko-
Autor(es): dc.creatorPavarino, Érika Cristina-
Autor(es): dc.creatorde Jesus Morais, Peterson-
Autor(es): dc.creatorPossebon, Vitória Scavacini-
Autor(es): dc.creatorJúnior, Vilson Serafim-
Autor(es): dc.creatorCastanhole-Nunes, Márcia Maria Urbanin-
Autor(es): dc.creatorGoloni-Bertollo, Eny Maria-
Data de aceite: dc.date.accessioned2025-08-21T16:47:37Z-
Data de disponibilização: dc.date.available2025-08-21T16:47:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2025.118024-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297797-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297797-
Descrição: dc.descriptionHypoxia in the tumor environment leads to an activation of genotypes that favors the tumor, promoting angiogenesis, epithelial-mesenchymal transition, cell invasion, and metastasis. It is considered a prognostic factor related to the progression and aggressiveness of Head and Neck Cancer (HNC). Hypoxia-inducible factor (HIF) is the main gene activated by hypoxia and has been associated with tumor advancement. Thus, this work aims to evaluate the performance of the compounds Acriflavine, Resveratrol, Topotecan, and RNA interference (siRNA) as HIF inhibitors as well as a therapeutic approach. Molecular docking results have suggested that the evaluated compounds present potential interactions with HIF-1α and HIF-2α. In vitro analysis, they demonstrated that treatments with Acriflavine and Topotecan caused a decrease in the gene expression of HIFs in the HN13 cell line (carcinoma of the oral cavity). Furthermore, treatments performed with siRNAs effectively inhibited gene expression of HIFs in HN13 and FaDu (carcinoma of the pharynx) cell lines. Considering the role of hypoxia and HIFs in tumor aggressiveness; the present study shows the potential of the evaluated compounds as a therapeutic use for the prevention of tumor progression in head and neck cancer.-
Descrição: dc.descriptionMolecular Biology and Genetics Research Unit– UPGEM Faculty of Medicine of São José do Rio Preto/SP – FAMERP, Av. Brigadeiro Faria Lima, 5416, Vila São Pedro, SP-
Descrição: dc.descriptionLaboratory of Molecular Markers and Bioinformatics– LMMB Faculty of Medicine of São José do Rio Preto/SP FAMERP, Av. Brigadeiro Faria Lima, 5416, Vila São Pedro, SP-
Descrição: dc.descriptionSão Paulo State University UNESP/IBILCE, R. Cristóvão Colombo, 2265 - Jardim Nazareth, SP-
Descrição: dc.descriptionSão Paulo State University UNESP/IBILCE, R. Cristóvão Colombo, 2265 - Jardim Nazareth, SP-
Idioma: dc.languageen-
Relação: dc.relationBiomedicine and Pharmacotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcriflavine-
Palavras-chave: dc.subjectHead Neck Neoplasms-
Palavras-chave: dc.subjectHypoxia-Inducible Factor-
Palavras-chave: dc.subjectInterfering-RNA-
Palavras-chave: dc.subjectResveratrol-
Palavras-chave: dc.subjectTopotecan-
Título: dc.titleEvaluation of hypoxia-inducible factor-1 and 2 alpha inhibitory compounds in the oral cavity and pharyngeal cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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