18th International HLA and Immunogenetics Workshop: Report on the SNP-HLA Reference Consortium (SHLARC) component

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Autor(es): dc.contributorEcole Centrale Nantes-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFinnish Red Cross Blood Service Biobank-
Autor(es): dc.contributorUniversity Hospital Schleswig Holstein - Campus Kiel-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital Sírio-Libanês-
Autor(es): dc.creatorSilva, Nayane S. B.-
Autor(es): dc.creatorBourguiba-Hachemi, Sonia-
Autor(es): dc.creatorDouillard, Venceslas-
Autor(es): dc.creatorKoskela, Satu-
Autor(es): dc.creatorDegenhardt, Frauke-
Autor(es): dc.creatorClancy, Jonna-
Autor(es): dc.creatorLimou, Sophie-
Autor(es): dc.creatorMeyer, Diogo-
Autor(es): dc.creatorMasotti, Cibele-
Autor(es): dc.creatorKnorst, Stefan-
Autor(es): dc.creatorNaslavsky, Michel Satya-
Autor(es): dc.creatorFranke, Andre-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorGourraud, Pierre-Antoine-
Autor(es): dc.creatorVince, Nicolas-
Data de aceite: dc.date.accessioned2025-08-21T20:53:05Z-
Data de disponibilização: dc.date.available2025-08-21T20:53:05Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/tan.15293-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297795-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297795-
Descrição: dc.descriptionThe SNP-HLA Reference Consortium (SHLARC), a component of the 18th International HLA and Immunogenetics Workshop, is aimed at collecting diverse and extensive human leukocyte antigen (HLA) data to create custom reference panels and enhance HLA imputation techniques. Genome-wide association studies (GWAS) have significantly contributed to identifying genetic associations with various diseases. The HLA genomic region has emerged as the top locus in GWAS, particularly in immune-related disorders. However, the limited information provided by single nucleotide polymorphisms (SNPs), the hallmark of GWAS, poses challenges, especially in the HLA region, where strong linkage disequilibrium (LD) spans several megabases. HLA imputation techniques have been developed using statistical inference in response to these challenges. These techniques enable the prediction of HLA alleles from genotyped GWAS SNPs. Here we present the SHLARC activities, a collaborative effort to create extensive, and multi-ethnic reference panels to enhance HLA imputation accuracy.-
Descrição: dc.descriptionInstitut National de la Santé et de la Recherche Médicale-
Descrição: dc.descriptionCenter for Research in Transplantation and Translational Immunology Nantes Université INSERM Ecole Centrale Nantes-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory School of Medicine São Paulo State University – Unesp-
Descrição: dc.descriptionFinnish Red Cross Blood Service Biobank-
Descrição: dc.descriptionInstitute of Clinical Molecular Biology Christian-Albrechts-University Kiel University Hospital Schleswig Holstein - Campus Kiel-
Descrição: dc.descriptionDepartment of Genetics and Evolutionary Biology Biosciences Institute University of São Paulo-
Descrição: dc.descriptionMolecular Oncology Center Hospital Sírio-Libanês-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory School of Medicine São Paulo State University – Unesp-
Idioma: dc.languageen-
Relação: dc.relationHLA-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject18th International HLA and Immunogenetics Workshop-
Palavras-chave: dc.subjectHLA-
Palavras-chave: dc.subjectimputation-
Palavras-chave: dc.subjectreference panel-
Palavras-chave: dc.subjectSHLARC-
Palavras-chave: dc.subjectSNP-
Título: dc.title18th International HLA and Immunogenetics Workshop: Report on the SNP-HLA Reference Consortium (SHLARC) component-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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