Ketoprofen Associated with Hyaluronic Acid Hydrogel for Temporomandibular Disorder Treatment: An In Vitro Study

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Autor(es): dc.contributorUniversity of Lyon-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Alfenas—UNIFAL-
Autor(es): dc.contributorParaíba Valley University-
Autor(es): dc.contributorUniversity of Leeds-
Autor(es): dc.contributorAnton-Paar-
Autor(es): dc.contributorNational Space Research Institute-
Autor(es): dc.contributorHospices Civils de Lyon-
Autor(es): dc.creatorMiranda, Diego Garcia-
Autor(es): dc.creatorRamos, Lucas de Paula-
Autor(es): dc.creatorLopes, Nicole Fernanda dos Santos-
Autor(es): dc.creatorSilva, Nicole Van Der Heijde Fernandes-
Autor(es): dc.creatorSoares, Cristina Pacheco-
Autor(es): dc.creatorRodrigues, Flavia Pires-
Autor(es): dc.creatorMorais, Vinicius de Paula-
Autor(es): dc.creatorSani-Taiariol, Thalita-
Autor(es): dc.creatorBaldan, Mauricio Ribeiro-
Autor(es): dc.creatorVasconcellos, Luana Marotta Reis de-
Autor(es): dc.creatorBorges, Alexandre Luiz Souto-
Autor(es): dc.creatorGrosgogeat, Brigitte-
Autor(es): dc.creatorGritsch, Kerstin-
Data de aceite: dc.date.accessioned2025-08-21T20:08:24Z-
Data de disponibilização: dc.date.available2025-08-21T20:08:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/gels10120811-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297756-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297756-
Descrição: dc.descriptionTemporomandibular disorders (TMD) are a public health problem that affects around 12% of the global population. The treatment is based on analgesics, non-steroidal anti-inflammatory, corticosteroids, anticonvulsants, or arthrocentesis associated with hyaluronic acid-based viscosupplementation. However, the use of hyaluronic acid alone in viscosupplementation does not seem to be enough to regulate the intra-articular inflammatory process. So, we propose to develop and evaluate the physicochemical and biological properties in vitro of hyaluronic acid hydrogels (HA) associated with ketoprofen (KET) as a new therapeutic treatment for TMD. The hydrogels were synthesized with 3% HA and 0.125, 0.250, 0.500, or 1% KET. Physicochemical analyses of Attenuated Total reflectance-Fourier transform infrared spectroscopy (FTIR), Thermogravimetry (TGA), Rheology by Frequency, Amplitude sweeps, temperature ramp, and scanning electron microscopy (SEM) were performed with or without sterilization and cycled. Cytocompatibility and genotoxicity (micronucleus assay) were performed in mouse macrophages (RAW 264-7) for 24 h. Results: FTIR spectrum showed characteristic absorptions of HA and KET. In the TGA, two mass loss peaks were observed, the first representing the water evaporation at 30 and 100 °C, and the second peaks between 200 and 300 °C, indicating the degradation of HA and KET. Rheology tests in the oscillatory regime classified the hydrogels as non-Newtonian fluids, time-dependent, and thixotropic. Mouse macrophages (RAW 264-7) presented viability of 83.6% for HA, 50.7% for KET, and 92.4%, 66.1%, 65.3%, and 87.7% for hydrogels, in addition to the absence of genotoxicity. Conclusions: Hyaluronic acid associated with ketoprofen shows satisfactory physicochemical and biological properties for use as viscosupplementation. As a limiting point of this study, further research is needed to evaluate the pharmacodynamic, toxicological, and pharmacokinetic characteristics of a complete organism.-
Descrição: dc.descriptionMultimaterials and Interfaces Laboratory (LMI) CNRS UMR 5615 University Claude Bernard Lyon 1 University of Lyon, 6 rue Victor Grignard-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University, Avenida Francisco José Longo 777, SP-
Descrição: dc.descriptionLaboratory “Health Systemic Process” (P2S) UR4129 Faculty of Medicine Laennec University Claude Bernard Lyon 1 University of Lyon, 7 rue Guillaume Paradin-
Descrição: dc.descriptionSchool of Dentistry Federal University of Alfenas—UNIFAL, R. Gabriel Monteiro da Silva, 700—CentroMG-
Descrição: dc.descriptionLaboratory of Cell Compartement Dynamics Research and Development Institute Paraíba Valley University, Avenida Shishima Hifumi 2911, SP-
Descrição: dc.descriptionOral Biology Division School of Dentistry Faculty of Medicine and Health University of Leeds-
Descrição: dc.descriptionAnton-Paar, Rua José de Magalhães 646, São Paulo, SP-
Descrição: dc.descriptionNational Space Research Institute, Avenida dos astronautas 1758, São José dos Campos 12227-010, SP-
Descrição: dc.descriptionDental School University Claude Bernard Lyon 1 University of Lyon, 7 rue Guillaume Paradin-
Descrição: dc.descriptionService d’Odontologie Hospices Civils de Lyon, 8 Rue de l’Université-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University, Avenida Francisco José Longo 777, SP-
Idioma: dc.languageen-
Relação: dc.relationGels-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectnon-steroidal anti-inflammatory agents 1-
Palavras-chave: dc.subjectosteoarthritis 3-
Palavras-chave: dc.subjectpolysaccharides 2-
Título: dc.titleKetoprofen Associated with Hyaluronic Acid Hydrogel for Temporomandibular Disorder Treatment: An In Vitro Study-
Tipo de arquivo: dc.typelivro digital-
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