Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSte. 301-
Autor(es): dc.contributorAriel University-
Autor(es): dc.contributorSheba Medical Center-
Autor(es): dc.contributorSaint Petersburg State University Russia-
Autor(es): dc.contributorCharité University Hospital-
Autor(es): dc.contributorTel Aviv University-
Autor(es): dc.contributorGeorge Washington University School of Medicine and Health Sciences-
Autor(es): dc.contributorMaimonides Medical Center-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKhyber Medical University-
Autor(es): dc.contributorCellTrend Gesellschaft mit beschränkter Haftung (GmbH)-
Autor(es): dc.contributorFederal University of Rio Grande do Norte-
Autor(es): dc.contributorR.N.-
Autor(es): dc.contributorand Seattle Children’s Research Institute-
Autor(es): dc.contributorTel-Aviv University-
Autor(es): dc.contributorUniversity Medical Center Schleswig-Holstein Campus Lübeck-
Autor(es): dc.contributorNYU Langone Medical Center-
Autor(es): dc.contributorJohns Hopkins University-
Autor(es): dc.contributorInc.-
Autor(es): dc.contributorCyrex Laboratories-
Autor(es): dc.contributorUniversal Scientific Education and Research Network (USERN)-
Autor(es): dc.creatorFonseca, Dennyson Leandro M.-
Autor(es): dc.creatorFilgueiras, Igor Salerno-
Autor(es): dc.creatorMarques, Alexandre H. C.-
Autor(es): dc.creatorVojdani, Elroy-
Autor(es): dc.creatorHalpert, Gilad-
Autor(es): dc.creatorOstrinski, Yuri-
Autor(es): dc.creatorBaiocchi, Gabriela Crispim-
Autor(es): dc.creatorPlaça, Desirée Rodrigues-
Autor(es): dc.creatorFreire, Paula P.-
Autor(es): dc.creatorPour, Shahab Zaki-
Autor(es): dc.creatorMoll, Guido-
Autor(es): dc.creatorCatar, Rusan-
Autor(es): dc.creatorLavi, Yael Bublil-
Autor(es): dc.creatorSilverberg, Jonathan I.-
Autor(es): dc.creatorZimmerman, Jason-
Autor(es): dc.creatorCabral-Miranda, Gustavo-
Autor(es): dc.creatorCarvalho, Robson F.-
Autor(es): dc.creatorKhan, Taj Ali-
Autor(es): dc.creatorHeidecke, Harald-
Autor(es): dc.creatorDalmolin, Rodrigo J. S.-
Autor(es): dc.creatorLuchessi, Andre Ducati-
Autor(es): dc.creatorOchs, Hans D.-
Autor(es): dc.creatorSchimke, Lena F.-
Autor(es): dc.creatorAmital, Howard-
Autor(es): dc.creatorRiemekasten, Gabriela-
Autor(es): dc.creatorZyskind, Israel-
Autor(es): dc.creatorRosenberg, Avi Z.-
Autor(es): dc.creatorVojdani, Aristo-
Autor(es): dc.creatorShoenfeld, Yehuda-
Autor(es): dc.creatorCabral-Marques, Otavio-
Data de aceite: dc.date.accessioned2025-08-21T20:39:40Z-
Data de disponibilização: dc.date.available2025-08-21T20:39:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41514-023-00118-0-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297741-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297741-
Descrição: dc.descriptionAge is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, and chronic respiratory disease). However, despite the well-known influence of age on autoantibody biology in health and disease, its impact on the risk of developing severe COVID-19 remains poorly explored. Here, we performed a cross-sectional study of autoantibodies directed against 58 targets associated with autoimmune diseases in 159 individuals with different COVID-19 severity (71 mild, 61 moderate, and 27 with severe symptoms) and 73 healthy controls. We found that the natural production of autoantibodies increases with age and is exacerbated by SARS-CoV-2 infection, mostly in severe COVID-19 patients. Multiple linear regression analysis showed that severe COVID-19 patients have a significant age-associated increase of autoantibody levels against 16 targets (e.g., amyloid β peptide, β catenin, cardiolipin, claudin, enteric nerve, fibulin, insulin receptor a, and platelet glycoprotein). Principal component analysis with spectrum decomposition and hierarchical clustering analysis based on these autoantibodies indicated an age-dependent stratification of severe COVID-19 patients. Random forest analysis ranked autoantibodies targeting cardiolipin, claudin, and platelet glycoprotein as the three most crucial autoantibodies for the stratification of severe COVID-19 patients ≥50 years of age. Follow-up analysis using binomial logistic regression found that anti-cardiolipin and anti-platelet glycoprotein autoantibodies significantly increased the likelihood of developing a severe COVID-19 phenotype with aging. These findings provide key insights to explain why aging increases the chance of developing more severe COVID-19 phenotypes.-
Descrição: dc.descriptionInterunit Postgraduate Program on Bioinformatics Institute of Mathematics and Statistics (IME) University of Sao Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of São Paulo, SP-
Descrição: dc.descriptionRegenera Medical 11860 Wilshire Blvd. Ste. 301-
Descrição: dc.descriptionAriel University-
Descrição: dc.descriptionZabludowicz Center for Autoimmune Diseases Sheba Medical Center-
Descrição: dc.descriptionSaint Petersburg State University Russia-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of São Paulo-
Descrição: dc.descriptionLaboratory of Molecular Evolution and Bioinformatics Department of Microbiology Biomedical Sciences Institute University of São Paulo-
Descrição: dc.descriptionDepartament of Nephrology and Internal Intensive Care Medicine Charité University Hospital-
Descrição: dc.descriptionScakler faculty of medicine Tel Aviv University-
Descrição: dc.descriptionDepartment of Dermatology George Washington University School of Medicine and Health Sciences-
Descrição: dc.descriptionMaimonides Medical Center-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP) Botucatu-
Descrição: dc.descriptionInstitute of Pathology and Diagnostic Medicine Khyber Medical University-
Descrição: dc.descriptionCellTrend Gesellschaft mit beschränkter Haftung (GmbH)-
Descrição: dc.descriptionBioinformatics Multidisciplinary Environment Federal University of Rio Grande do Norte-
Descrição: dc.descriptionDepartment of Biochemistry Federal University of Rio Grande do Norte-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Federal University of Rio Grande do Norte R.N.-
Descrição: dc.descriptionDepartment of Pediatrics University of Washington School of Medicine and Seattle Children’s Research Institute-
Descrição: dc.descriptionDepartment of Medicine B Sheba Medical Center-
Descrição: dc.descriptionSackler Faculty of Medicine Tel-Aviv University-
Descrição: dc.descriptionDepartment of Rheumatology University Medical Center Schleswig-Holstein Campus Lübeck-
Descrição: dc.descriptionDepartment of Pediatrics NYU Langone Medical Center-
Descrição: dc.descriptionDepartment of Pathology Johns Hopkins University-
Descrição: dc.descriptionDepartment of Immunology Immunosciences Laboratory Inc.-
Descrição: dc.descriptionCyrex Laboratories, LLC 2602 S. 24th St.-
Descrição: dc.descriptionDepartment of Pharmacy and Postgraduate Program of Health and Science Federal University of Rio Grande do Norte-
Descrição: dc.descriptionDepartment of Medicine Division of Molecular Medicine University of São Paulo School of Medicine-
Descrição: dc.descriptionLaboratory of Medical Investigation 29 University of São Paulo School of Medicine-
Descrição: dc.descriptionNetwork of Immunity in Infection Malignancy Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN), SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP) Botucatu-
Idioma: dc.languageen-
Relação: dc.relationnpj Aging-
???dc.source???: dc.sourceScopus-
Título: dc.titleSevere COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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