Morphological and biomechanical characterization of long bones and peri-implant bone repair in type 2 diabetic rats treated with resveratrol

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.creatorWajima, Carolina Sayuri-
Autor(es): dc.creatorPitol-Palin, Letícia-
Autor(es): dc.creatorde Souza Batista, Fábio Roberto-
Autor(es): dc.creatordos Santos, Paulo Henrique-
Autor(es): dc.creatorMatsushita, Doris Hissako-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T18:43:37Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-024-53260-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297738-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297738-
Descrição: dc.descriptionType 2 diabetes interferes with bone remodeling mechanisms, requiring studies to reverse this damage, and resveratrol is a polyphenol with rich properties. This study aimed to characterize the long bone morphology and peri-implant biomechanics of normoglycemic and type 2 diabetic animals treated with resveratrol. Thirty-two male Wistar rats were used and divided into normoglycemic and diabetic with or without treatment. They had the installation of implants in the tibia and treatment with oral resveratrol within 45 days. Resveratrol was responsible for weight homeostasis and decreased glycemic levels in rats with type 2 diabetes. The three-point bending testing, resveratrol showed positive effects on the biomechanics of long bones, corroborating a more resistant bone in comparison to untreated diabetics. Micro-ct revealed how bone metabolism is affected by systemic disease, decreasing bone quality. The counter-torque of normoglycemic animals showed superior osseointegration to diabetes, with no differences in the administration of the polyphenol, showing the sovereignty of the deleterious effects of the disease when there is a tissue lesion and an inflammatory picture installed. Overall, resveratrol acted positively in the etiopathogenesis of type 2 diabetes and revealed positive effects on the strength of long bones.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Basic Science Araçatuba School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFaculty of Dentistry - Restorative Dentistry Area University of Toronto-
Descrição: dc.descriptionDepartment of Basic Science Araçatuba School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2019/01634-0-
Descrição: dc.descriptionFAPESP: 2019/19019-0-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleMorphological and biomechanical characterization of long bones and peri-implant bone repair in type 2 diabetic rats treated with resveratrol-
Tipo de arquivo: dc.typelivro digital-
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