Metabolic, Inflammatory, and Molecular Impact of Cancer Cachexia on the Liver

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGonçalves, Daniela Caetano-
Autor(es): dc.creatorGomes, Silvio Pires-
Autor(es): dc.creatorSeelaender, Marília-
Data de aceite: dc.date.accessioned2025-08-21T23:45:53Z-
Data de disponibilização: dc.date.available2025-08-21T23:45:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms252211945-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297622-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297622-
Descrição: dc.descriptionCancer-associated cachexia (CAC) is a severe wasting syndrome, marked by involuntary weight loss and muscle wasting. It is a leading cause of cancer-related morbidity and mortality, and is driven by systemic, chronic low-grade inflammation. Key cytokines, such as IL-6 and GDF15, activate catabolic pathways in many organs. This study examined the role of inflammation and metabolic disruption in the liver during CAC, focusing on its dual role as both a target and a source of inflammatory factors. The analysis covered protein and lipid metabolism disturbances, including the hepatic production of acute-phase proteins and insulin resistance. Hepatic inflammation contributes to systemic dysfunction in CAC. The increased production of C-Reactive Protein (CRP) impacts muscle wasting, while liver inflammation leads to insulin resistance and hepatic steatosis, aggravating the cachectic state. Therefore, understanding the molecular mechanisms of liver metabolism in CAC is essential for developing effective therapies. Potential interventions include anti-inflammatory treatments, anabolic strategies, and restoration of lipid metabolism. Further research is necessary to explore the liver’s full contribution to CAC and its systemic effects, allowing to the development of liver-targeted therapeutic strategies.-
Descrição: dc.descriptionDepartamento de Biociências Universidade Federal de São Paulo (UNIFESP)-
Descrição: dc.descriptionInstituto de Biociências (IBB) Departamento de Biologia Estrutural e Funcional Anatomy Sector Universidade Estadual Paulista (Unesp), Câmpus Botucatu, São Paulo-
Descrição: dc.descriptionLIM 26-HC Departamento de Cirurgia Faculdade de Medicina da Universidade de São Paulo-
Descrição: dc.descriptionInstituto de Biociências (IBB) Departamento de Biologia Estrutural e Funcional Anatomy Sector Universidade Estadual Paulista (Unesp), Câmpus Botucatu, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcachexia-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectliver-
Palavras-chave: dc.subjectmetabolism-
Título: dc.titleMetabolic, Inflammatory, and Molecular Impact of Cancer Cachexia on the Liver-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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