Assessment of sexual function in postmenopausal breast cancer survivors

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVitorino, Caroline Nakano-
Autor(es): dc.creatorOmodei, Michelle Sako-
Autor(es): dc.creatorDe Souza, Rafaela Caroline-
Autor(es): dc.creatorNahas, Georgia Petri-
Autor(es): dc.creatorDe Araujo Brito Buttros, Daniel-
Autor(es): dc.creatorCarvalho-Pessoa, Eduardo-
Autor(es): dc.creatorVespoli, Heloisa De Luca-
Autor(es): dc.creatorNahas, Eliana Aguiar Petri-
Data de aceite: dc.date.accessioned2025-08-21T20:34:46Z-
Data de disponibilização: dc.date.available2025-08-21T20:34:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/sexmed/qfae035-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297604-
Descrição: dc.descriptionBackground: Breast cancer (BC) is considered a risk factor for sexual dysfunction, which may be associated with the diagnosis itself or with oncological treatments. However, sexual dysfunction often remains underdiagnosed and unaddressed among BC survivors. Aim: The study sought to evaluate the sexual function of postmenopausal BC survivors compared with postmenopausal women without BC. Methods: This case-control study included 178 postmenopausal BC survivors (stages I-III), 45 to 70 years of age, with amenorrhea for ≥12 months and sexually active. They were compared with 178 women without BC, matched (±2 years) for age and time since menopause in a 1:1 ratio. Sexual function was evaluated using the Female Sexual Function Index (FSFI), which consists of 6 domains (desire, arousal, lubrication, orgasm, satisfaction, and pain), with a total score ≤26.5 indicating risk of sexual dysfunction. Statistical analysis included Student's t test, chi-square test, and logistic regression (odds ratio [OR]). Outcomes: Evaluation of sexual function in postmenopausal women treated for BC. Results: Postmenopausal BC survivors showed poorer sexual function in the desire domain (P =. 002). No significant differences were observed between groups in the other FSFI domains and total score (P >. 05). Postmenopausal BC survivors had a higher prevalence of risk of sexual dysfunction (64.6% with a total score ≤26.5) compared with the control group (51.6%) (P =. 010). Adjusted risk analysis for age and time since menopause revealed a higher risk of sexual dysfunction in BC survivors compared with women without cancer (OR, 1.98; 95% confidence interval, 1.29-2.96; P =. 007). Among BC survivors, the use of hormone therapy was associated with a higher risk of sexual dysfunction (OR, 3.46; 95% confidence interval, 1.59-7.51; P =. 002). Clinical Implications: Postmenopausal BC survivors should be regularly assessed before and throughout treatment to enable the early detection and diagnosis of sexual dysfunction. Strength and Limitations: The main strength is that this study might contribute to a better understanding of sexual function in postmenopausal BC survivors compared with women without BC. The main limitation is that while the FSFI is a valid and reliable tool for the evaluation of female sexual function, it does not allow a comprehensive diagnosis of sexual dysfunction, as it is not applicable to partners. Conclusion: Compared with postmenopausal women without BC, postmenopausal BC survivors face a higher risk of sexual dysfunction, especially when treated with adjuvant hormone therapy.-
Descrição: dc.descriptionGraduate Program in Obstetrics and Gynecology Medical School São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Medical School São Paulo State University, Botucatu-
Descrição: dc.descriptionGraduate Program in Obstetrics and Gynecology Medical School São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology Medical School São Paulo State University, Botucatu-
Idioma: dc.languageen-
Relação: dc.relationSexual Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbreast cancer-
Palavras-chave: dc.subjectmenopause-
Palavras-chave: dc.subjectsexual function-
Título: dc.titleAssessment of sexual function in postmenopausal breast cancer survivors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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