Exploratory comparative transcriptomic analysis reveals potential gene targets associated with Cry1A.105 and Cry2Ab2 resistance in fall armyworm (Spodoptera frugiperda)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIPBEN-
Autor(es): dc.creatorCastellane, Tereza Cristina L.-
Autor(es): dc.creatorFernandes, Camila C.-
Autor(es): dc.creatorPinheiro, Daniel G.-
Autor(es): dc.creatorLemos, Manoel Victor Franco-
Autor(es): dc.creatorVarani, Alessandro M.-
Data de aceite: dc.date.accessioned2025-08-21T22:21:21Z-
Data de disponibilização: dc.date.available2025-08-21T22:21:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10142-024-01408-w-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297568-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297568-
Descrição: dc.descriptionGenetically modified (GM) crops, expressing Bacillus thuringiensis (Bt) insecticidal toxins, have substantially transformed agriculture. Despite rapid adoption, their environmental and economic benefits face scrutiny due to unsustainable agricultural practices and the emergence of resistant pests like Spodoptera frugiperda, known as the fall armyworm (FAW). FAW’s adaptation to Bt technology in corn and cotton compromises the long-term efficacy of Bt crops. To advance the understanding of the genetic foundations of resistance mechanisms, we conducted an exploratory comparative transcriptomic analysis of two divergent FAW populations. One population exhibited practical resistance to the Bt insecticidal proteins Cry1A.105 and Cry2Ab2, expressed in the genetically engineered MON-89Ø34 − 3 maize, while the other population remained susceptible to these proteins. Differential expression analysis supported that Cry1A.105 and Cry2Ab2 significantly affect the FAW physiology. A total of 247 and 254 differentially expressed genes were identified in the Cry-resistant and susceptible populations, respectively. By integrating our findings with established literature and databases, we underscored 53 gene targets potentially involved in FAW’s resistance to Cry1A.105 and Cry2Ab2. In particular, we considered and discussed the potential roles of the differentially expressed genes encoding ABC transporters, G protein-coupled receptors, the P450 enzymatic system, and other Bt-related detoxification genes. Based on these findings, we emphasize the importance of exploratory transcriptomic analyses to uncover potential gene targets involved with Bt insecticidal proteins resistance, and to support the advantages of GM crops in the face of emerging challenges.-
Descrição: dc.descriptionDepartamento de Biologia Faculdade de Ciências Agrárias E Veterinárias Universidade Estadual Paulista (UNESP), Rod. Prof. Paulo Donato Castellane km 5, SP-
Descrição: dc.descriptionInstituto de Pesquisa em Bioenergia Laboratório Multiusuário de Sequenciamento em Larga Escala e Expressão Gênica IPBEN, SP-
Descrição: dc.descriptionDepartamento de Biotecnologia Agropecuária e Ambiental Faculdade de Ciências Agrárias E Veterinárias Universidade Estadual Paulista (UNESP), Rod. Prof. Paulo Donato Castellane km 5, SP-
Descrição: dc.descriptionDepartamento de Biologia Faculdade de Ciências Agrárias E Veterinárias Universidade Estadual Paulista (UNESP), Rod. Prof. Paulo Donato Castellane km 5, SP-
Descrição: dc.descriptionDepartamento de Biotecnologia Agropecuária e Ambiental Faculdade de Ciências Agrárias E Veterinárias Universidade Estadual Paulista (UNESP), Rod. Prof. Paulo Donato Castellane km 5, SP-
Idioma: dc.languageen-
Relação: dc.relationFunctional and Integrative Genomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrazilian corn field-
Palavras-chave: dc.subjectCrystal proteins-
Palavras-chave: dc.subjectPhase I detoxification enzymes-
Palavras-chave: dc.subjectPhase II metabolism enzymes-
Palavras-chave: dc.subjectPhase III transporters-
Palavras-chave: dc.subjectPlant-pest interactions-
Título: dc.titleExploratory comparative transcriptomic analysis reveals potential gene targets associated with Cry1A.105 and Cry2Ab2 resistance in fall armyworm (Spodoptera frugiperda)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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