Proposal for the applicability of modified Breslow (measured from the basal membrane) as a predictor of survival and sentinel lymph node outcome in patients with cutaneous melanoma

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Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital Amaral Carvalho-
Autor(es): dc.contributorCentro Universitário Unisalesiano Auxilium-
Autor(es): dc.contributorInstituto de Patologia de Araçatuba-
Autor(es): dc.creatorAsato, Marcel Arakaki-
Autor(es): dc.creatorMoares Neto, Francisco Alves-
Autor(es): dc.creatorMoraes, Marcelo Padovani de Toledo-
Autor(es): dc.creatorOcanha-Xavier, Juliana Polizel-
Autor(es): dc.creatorTakita, Luiz Carlos-
Autor(es): dc.creatorMarques, Mariangela Esther Alencar-
Autor(es): dc.creatorXavier-Júnior, José Cândido Caldeira-
Data de aceite: dc.date.accessioned2025-08-21T19:18:19Z-
Data de disponibilização: dc.date.available2025-08-21T19:18:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.abd.2023.09.002-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297562-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297562-
Descrição: dc.descriptionBackground: Cutaneous melanoma is a neoplasm with a high mortality rate and risk of metastases to distant organs. The Breslow micrometric measurement is considered the most important factor for evaluating prognosis and management, measured from the granular layer to the deepest portion of the neoplasm. Despite its widespread use, the Breslow thickness measurement has some inaccuracies, such as not considering variations in the thickness of the epidermis in different body locations or when there is ulceration. Objective: To evaluate the applicability of a modified Breslow measurement, measured from the basal membrane instead of from the granular layer, in an attempt to predict sentinel lymph node examination outcome and survival of patients with melanoma. Methods: A retrospective and cross-sectional analysis was carried out based on the evaluation of slides stained with hematoxylin & eosin from 275 cases of melanoma that underwent sentinel lymph node biopsy from 2008 to 2021 at a reference center in Brazil. Results: Analysis of the Cox model to evaluate the impact of the Breslow measurement and the modified Breslow measurement on survival showed that both methods are statistically significant. Logistic regression revealed a significant association between both measurements and the presence of metastasis in sentinel lymph nodes. Conclusion: Measuring melanoma depth from the basal membrane (modified Breslow measurement) is capable of predicting survival time and sentinel lymph node outcome, as well as the conventional Breslow measurement.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFaculty of Medicine Universidade Federal de Mato Grosso do Sul, MS-
Descrição: dc.descriptionDepartment of Pathology Faculty of Medicine Universidade Estadual Paulista, SP-
Descrição: dc.descriptionPathological Anatomy Laboratory Hospital Amaral Carvalho, SP-
Descrição: dc.descriptionFaculty of Medicine Centro Universitário Unisalesiano Auxilium, SP-
Descrição: dc.descriptionDepartment of Dermatopathology Instituto de Patologia de Araçatuba, SP-
Descrição: dc.descriptionDepartment of Pathology Faculty of Medicine Universidade Estadual Paulista, SP-
Formato: dc.format398-406-
Idioma: dc.languageen-
Relação: dc.relationAnais Brasileiros de Dermatologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMelanoma-
Palavras-chave: dc.subjectNeoplasm staging-
Palavras-chave: dc.subjectPathology-
Palavras-chave: dc.subjectSkin neoplasms-
Título: dc.titleProposal for the applicability of modified Breslow (measured from the basal membrane) as a predictor of survival and sentinel lymph node outcome in patients with cutaneous melanoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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