Duguetia furfuracea (A.ST. Hil.) Saff.: Neuroprotective Effect on Chemically Induced Amnesia, Anxiolytic Effects and Preclinical Safety Evaluation in Mice

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Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorFava de Souza, Maiara-
Autor(es): dc.creatorMaurino dos Santos, Jéssica-
Autor(es): dc.creatorMariano dos Santos, Sidney-
Autor(es): dc.creatorCruz de Oliveira Junior, Pedro-
Autor(es): dc.creatorAlberto Marangoni Faoro, Janaine-
Autor(es): dc.creatorArena, Arielle Cristina-
Autor(es): dc.creatorNagaoka, Lívia Trippe-
Autor(es): dc.creatorGauze, Gisele de Freitas-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorHenrique Barbim Rech, Matheus-
Autor(es): dc.creatorMara Mussury Franco Silva, Rosilda-
Autor(es): dc.creatorFormagio, Anelise Samara Nazari-
Data de aceite: dc.date.accessioned2025-08-21T15:25:21Z-
Data de disponibilização: dc.date.available2025-08-21T15:25:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biology13120981-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297535-
Descrição: dc.descriptionDuguetia furfuracea, “araticum-seco”, is known to contain several bioactive compounds that can mitigate oxidative stress and act on the central nervous system (CNS). This effect is partly attributed to its potent antioxidant and acetylcholinesterase (AChE) inhibitors. In this study, the effects were explored of the methanolic extract (MEDF) and alkaloid fraction (AFDF) of D. furfuracea (leaves) on cognitive behaviors in male mice with scopolamine (Scop)-induced cognitive impairment and biochemical parameters. Additionally, anxiolytic behavior, subacute toxicity, molecular docking and antioxidant activity were reported. MEDF (30, 100 or 300 mg/kg) or AFDF (30 mg/kg) were orally administered for 16 days and Scop (intraperitoneally, i.p.) between days 11 and 16. The anxiolytic behavior (open field test and marble burying) in healthy mice, and the Scop-induced memory impairment (object recognition test and Morris water maze (MWM)) were assessed, and the biochemical parameters (malondialdehyde (MDA) and AChE levels) were measured after euthanasia. The subacute toxicological impact of MEDF was assessed in female Swiss mice for 28 days. MEDF and AFDF were available for the DPPH, ABTS and β-carotene/linoleic acid models. The results revealed that MEDF and AFDF exhibit anxiolytic effects and significantly alleviated Sco-induced memory impairment, inhibited AChE in the cortex (40%) and MDA (51.51%) levels. Reticuline was reported in AFDF and molecular coupling with AChE involves link-type hydrogen bonds and van der Waals interactions. MEDF exhibited antioxidant capacity (DPPH, IC50 = 18.10 ± 1.70 µg/mL; ABTS, IC50 = 10.41 ± 1.69 µg/mL). MEDF did not reveal signs of toxicity. In conclusion, D. furfuracea shows promise in mitigating scopolamine-induced memory deficits, potentially because it inhibits AChE activity, reduces MDA levels, and enhances antioxidant activities.-
Descrição: dc.descriptionCollege of Health Science Federal University of Grande Dourados, MS-
Descrição: dc.descriptionCollege of Biological and Environmental Sciences Federal University of Grande Dourados, MS-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu Department of Structural and Functional Biology University Estadual Paulista—Botucatu (UNESP), SP-
Descrição: dc.descriptionDepartment of Chemistry State University of Maringá UEM, PR-
Descrição: dc.descriptionCentro de Estudos em Células-Tronco Terapia Celular e Genética Toxicológica (CeTroGen) Faculdade de Medicina (FAMED) Universidade Federal de Mato Grosso do Sul (UFMS), MS-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu Department of Structural and Functional Biology University Estadual Paulista—Botucatu (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationBiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAChE-
Palavras-chave: dc.subjectanxiety-
Palavras-chave: dc.subjectdementia-
Palavras-chave: dc.subjectscopolamine-
Palavras-chave: dc.subject“araticum seco”-
Título: dc.titleDuguetia furfuracea (A.ST. Hil.) Saff.: Neuroprotective Effect on Chemically Induced Amnesia, Anxiolytic Effects and Preclinical Safety Evaluation in Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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