Development of a “turn off” fluorescent molecularly imprinted nanoparticle-based sensor for selective captopril quantification in synthetic urine and wastewater samples

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilva, Weida Rodrigues-
Autor(es): dc.creatorOliveira, Lara Fábia Magalhães-
Autor(es): dc.creatorSotomayor, Maria del Pilar Taboada-
Autor(es): dc.creatorPetruci, João Flávio da Silveira-
Data de aceite: dc.date.accessioned2025-08-21T16:00:06Z-
Data de disponibilização: dc.date.available2025-08-21T16:00:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00604-024-06446-6-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297523-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297523-
Descrição: dc.descriptionThe combination of silica nanoparticles with fluorescent molecularly imprinted polymers (Si-FMIPs) prepared by a one-pot sol-gel synthesis method to act as chemical sensors for the selective and sensitive determination of captopril is described. Several analytical parameters were optimized, including reagent ratio, solvent, concentration of Si-FMIP solutions, and contact time. Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and the ninhydrin assay were used for characterization. The selectivity was evaluated against molecules belonging to other drug classes, such as fluoroquinolones, nonacid nonopioids, benzothiadiazine, alpha amino acids, and nitroimidazoles. Under optimized conditions, the Si-FMIP-based sensor exhibited a working range of 1–15 µM, with a limit of detection (LOD) of 0.7 µM, repeatability of 6.4% (n = 10), and suitable recovery values at three concentration levels (98.5% (1.5 µM), 99.9% (3.5 µM), and 99.2% (7.5 µM)) for wastewater samples. The sensor provided a working range of 0.5–15 µM for synthetic urine samples, with an LOD of 0.4 µM and a repeatability of 7.4% (n = 10) and recovery values of 93.7%, 92.9%, and 98.0% for 1.0 µM, 3.5 µM, and 10 µM, respectively. In conclusion, our single-vessel synthesis approach for Si-FMIPs proved to be highly effective for the selective determination of captopril in wastewater and synthetic urine samples. Graphical abstract: (Figure presented.)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Uberlândia (UFU), MG-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP) and National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Agents (INCT−DATREM)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP) and National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Agents (INCT−DATREM)-
Descrição: dc.descriptionCNPq: 141054/2020-4-
Descrição: dc.descriptionFAPESP: 2014/50945–4-
Descrição: dc.descriptionCNPq: 403929/2021-0-
Descrição: dc.descriptionCNPq: 465571/2014–0-
Descrição: dc.descriptionFAPEMIG: APQ-00196-22-
Idioma: dc.languageen-
Relação: dc.relationMicrochimica Acta-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaptopril-
Palavras-chave: dc.subjectFluorescence detection-
Palavras-chave: dc.subjectMolecularly imprinted polymers-
Palavras-chave: dc.subjectOne-pot synthesis-
Palavras-chave: dc.subjectPotential emerging pollutants-
Título: dc.titleDevelopment of a “turn off” fluorescent molecularly imprinted nanoparticle-based sensor for selective captopril quantification in synthetic urine and wastewater samples-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.