Soft autonomous ingestible device for sampling the small-intestinal microbiome

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorTufts University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHarvard School of Public Health-
Autor(es): dc.creatorDel-Rio-Ruiz, Ruben-
Autor(es): dc.creatorRomualdo da Silva, Debora Regina-
Autor(es): dc.creatorSuresh, Hasika-
Autor(es): dc.creatorCreasey, Hannah-
Autor(es): dc.creatorAsci, Cihan-
Autor(es): dc.creatordos Santos, Danilo M.-
Autor(es): dc.creatorSharma, Atul-
Autor(es): dc.creatorWidmer, Giovanni-
Autor(es): dc.creatorSonkusale, Sameer-
Data de aceite: dc.date.accessioned2025-08-21T22:53:06Z-
Data de disponibilização: dc.date.available2025-08-21T22:53:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-16-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.device.2024.100406-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297439-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297439-
Descrição: dc.descriptionThe gut microbiota is linked to many medical conditions, but our understanding is limited by the lack of affordable, non-invasive ways to sample it. Ingestible devices offer solutions, but current models are complex and can suffer from sample contamination. Consequently, we developed a 3D-printed ingestible device that is elastic, lightweight, low cost, and biocompatible. It collects small-intestinal content via pH-triggered sidewall inlets. Elastic microvalves with swellable beads autonomously close the inlets to prevent contamination. Consistent with bench-scale experimentation, tests in animals demonstrate that the bacterial populations recovered by the pills closely resemble the bacterial populations recovered post mortem from the small intestine. In contrast to the fecal microbiota, samples collected by the ingestible devices were more diverse and were characterized by a lower bacterial concentration than is found in feces. Our non-invasive and cost-effective gut sampling device is expected to advance our understanding of the role of the small-intestinal microbiota.-
Descrição: dc.descriptionMassachusetts Life Sciences Center-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionDepartment of Electrical and Computer Engineering Tufts University-
Descrição: dc.descriptionNano Lab Tufts University-
Descrição: dc.descriptionDepartment of Infectious Diseases and Global Health Cummings School of Veterinary Medicine Tufts University-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine, São Paulo-
Descrição: dc.descriptionHarvard School of Public Health, 77 Avenue Louis Pasteur-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine, São Paulo-
Descrição: dc.descriptionNational Institutes of Health: R21AI144521-
Descrição: dc.descriptionNational Institutes of Health: R21DK132314-
Idioma: dc.languageen-
Relação: dc.relationDevice-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject16S amplicon sequencing-
Palavras-chave: dc.subject3D printing-
Palavras-chave: dc.subjectDTI-3-
Palavras-chave: dc.subjectgut microbiota-
Palavras-chave: dc.subjectingestible device-
Palavras-chave: dc.subjectlocking microvalves-
Palavras-chave: dc.subjectnon-invasive sampling-
Palavras-chave: dc.subjectpill-
Título: dc.titleSoft autonomous ingestible device for sampling the small-intestinal microbiome-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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