Genome-wide association study for milk yield, frame, and udder-conformation traits of Gir dairy cattle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFundación Universitaria Agraria de Colombia-UNIAGRARIA-
Autor(es): dc.contributorSchool of Chemistry and Molecular Biosciences-
Autor(es): dc.contributorIUDigital-
Autor(es): dc.creatorDominguez-Castaño, P.-
Autor(es): dc.creatorFortes, M.-
Autor(es): dc.creatorTan, W. L.A.-
Autor(es): dc.creatorToro-Ospina, A. M.-
Autor(es): dc.creatorSilva, J. A. II V.-
Data de aceite: dc.date.accessioned2025-08-21T19:26:50Z-
Data de disponibilização: dc.date.available2025-08-21T19:26:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3168/jds.2024-24648-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297427-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297427-
Descrição: dc.descriptionGenome-wide association studies are employed to identify genomic regions and candidate genes associated with several traits. The aim of this study was to perform a GWAS to identify causative variants and genes associated with milk yield, frame, and udder-conformation traits in Gir dairy cattle. Body conformation traits were classified as “frame,” and “udder” traits for this study. After genotyping imputation and quality control 42,105 polymorphisms were available for analyses and 24,489 cows with pedigree information had phenotypes. First, P-value was calculated based on the variance of the prediction error of the SNP effects on the first iteration. After that, 2 more iterations were performed to carry out the weighted single-step genome-wide association methodology, performed using genomic moving windows defined based on linkage disequilibrium. The significant SNPs and top 10 windows explaining the highest percentage of additive genetic variance were selected and used for QTL and gene annotation. The variants identified in our work overlapped with QTL from the animal QTL database on chromosomes 1 to 23, except for chromosome 4. The Gir breed is less studied than the Holstein breed and as such the animal QTL database is biased to Holstein results. Hence it is noteworthy that our GWAS had similarities with previously described QTL. These previously known QTL were related to milk yield, body height, rump angle, udder width, and udder depth. In total, 5 genes were annotated. Of these genes, FAM13A and CMSS1 had been previously related to bone and carcass weight in cattle.-
Descrição: dc.descriptionFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista Jaboticabal-
Descrição: dc.descriptionFacultad de Ciências Agrárias Fundación Universitaria Agraria de Colombia-UNIAGRARIA-
Descrição: dc.descriptionThe University of Queensland School of Chemistry and Molecular Biosciences, Queensland-
Descrição: dc.descriptionScience and Humanities Faculty Digital University Institute of Antioquia IUDigital-
Descrição: dc.descriptionFaculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista, São Paulo-
Descrição: dc.descriptionFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista Jaboticabal-
Descrição: dc.descriptionFaculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista, São Paulo-
Formato: dc.format11127-11138-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dairy Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbody conformation traits-
Palavras-chave: dc.subjectBos taurus indicus cattle-
Palavras-chave: dc.subjectcandidate genes-
Palavras-chave: dc.subjectdairy cattle-
Palavras-chave: dc.subjectgenome-wide association-
Título: dc.titleGenome-wide association study for milk yield, frame, and udder-conformation traits of Gir dairy cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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