Garcinia brasiliensis Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPadre Albino University Center (UNIFIPA)-
Autor(es): dc.contributorUniversity of Aveiro-
Autor(es): dc.creatorSilva, Lucas Sylvestre-
Autor(es): dc.creatorCavallini, Eduardo-
Autor(es): dc.creatorda Silva, Rafael André-
Autor(es): dc.creatorSant’Ana, Monielle-
Autor(es): dc.creatorYoshikawa, Ariane Harumi-
Autor(es): dc.creatorSalomão, Thiago-
Autor(es): dc.creatorHuang, Bianca-
Autor(es): dc.creatorCraice, Paula-
Autor(es): dc.creatorde Souza Ferreira, Luiz Philipe-
Autor(es): dc.creatorDella Matta, Heitor Pedro-
Autor(es): dc.creatorGil, Cristiane Damas-
Autor(es): dc.creatorPereira, Maria de Lourdes Gomes-
Autor(es): dc.creatorGirol, Ana Paula-
Data de aceite: dc.date.accessioned2025-08-21T22:52:49Z-
Data de disponibilização: dc.date.available2025-08-21T22:52:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph18010024-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297396-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297396-
Descrição: dc.descriptionBackground: Garcinia brasiliensis is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from G. brasiliensis leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. Methods: Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment. Biochemical analyses were also performed to evaluate in vivo cytotoxicity. In relation to tumor-induced animals, morphological changes, plasma enzymes, inflammatory mediators and the induction of apoptosis were analyzed, in addition to histopathological studies, to evaluate the inhibition of tumor growth. Results: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) were regulated by CE and EAF administration. Furthermore, both treatments were effective in inhibiting tumor growth in EA and ES by modulating the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, decreasing mast cells numbers and inducing apoptosis. Conclusions: This research indicates that both CE and EAF from G. brasiliensis leaves have potential antitumor effects with low cytotoxicity.-
Descrição: dc.descriptionPost Graduate Program in Structural and Functional Biology Paulista School of Medicine (UNIFESP-EPM) Federal University of São Paulo, São Paulo, SP-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionExperimental and Clinical Research Center (CEPEC) Padre Albino University Center (UNIFIPA), SP-
Descrição: dc.descriptionCICECO-Aveiro Institute of Materials Department of Medical Sciences University of Aveiro-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidant-
Palavras-chave: dc.subjectantitumor-
Palavras-chave: dc.subjectEhrlich tumor-
Palavras-chave: dc.subjectGarcinia brasiliensis-
Título: dc.titleGarcinia brasiliensis Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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