Bioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

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Autor(es): dc.contributorNational Heart and Lung Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Anhanguera de São Paulo (UNIAN)-
Autor(es): dc.contributorFundação Nacional de Gestão de Saúde-
Autor(es): dc.contributorUniversidade Nove de Julho-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorInc-
Autor(es): dc.contributorUniderp Anhanguera University-
Autor(es): dc.contributorUniversity of Cuiabá (UNIC)-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorRodrigues, Daniel-
Autor(es): dc.creatorOhara, Rie-
Autor(es): dc.creatorAlmeida, Nara Lígia Martins-
Autor(es): dc.creatorLara, Vanessa Soares-
Autor(es): dc.creatorSartorelli, Patricia-
Autor(es): dc.creatorGraeff, Carlos Frederico de Oliveira-
Autor(es): dc.creatorGrecco, Simone dos Santos-
Autor(es): dc.creatorGonzález, Alejandra Hortencia Miranda-
Autor(es): dc.creatorD’Alpino, Paulo Henrique Perlatti-
Data de aceite: dc.date.accessioned2025-08-21T18:24:47Z-
Data de disponibilização: dc.date.available2025-08-21T18:24:47Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/tswj/9466270-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297372-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297372-
Descrição: dc.descriptionChronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bioactivity in in vitro and in vivo studies, contributing to the development of innovative and sustainable wound management therapies.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionImperial College London National Heart and Lung Institute, imperial.ac.uk, GBR-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), São Paulo, unesp.br, BRA-
Descrição: dc.descriptionBioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP), unesp.br, BRA-
Descrição: dc.descriptionBiotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN), São Paulo, BRA-
Descrição: dc.descriptionDepartment of Health Management Fundação Nacional de Gestão de Saúde-
Descrição: dc.descriptionUndergraduate Program Medical School Universidade Nove de Julho, Bauru-
Descrição: dc.descriptionDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP), São Paulo, usp.br, BRA-
Descrição: dc.descriptionDepartment of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo, São Paulo, unifesp.br, BRA-
Descrição: dc.descriptionDepartment of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc, Bauru-
Descrição: dc.descriptionPost-Graduate Program in Dentistry Uniderp Anhanguera University, Mato Grosso do Sul-
Descrição: dc.descriptionPost-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC), Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Physics School of Sciences São Paulo State University (UNESP), São Paulo, unesp.br, BRA-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), São Paulo, unesp.br, BRA-
Descrição: dc.descriptionBioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP), unesp.br, BRA-
Descrição: dc.descriptionDepartment of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Physics School of Sciences São Paulo State University (UNESP), São Paulo, unesp.br, BRA-
Descrição: dc.descriptionFAPESP: 2023/00460-3-
Idioma: dc.languageen-
Relação: dc.relationScientific World Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiocompatibility-
Palavras-chave: dc.subjectchronic wounds-
Palavras-chave: dc.subjectnatural compounds-
Palavras-chave: dc.subjectpreclinical tests-
Palavras-chave: dc.subjectwound care-
Título: dc.titleBioactivity, Efficacy, and Safety of a Wound Healing Ointment With Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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