Embryotoxicity Induced by Triclopyr in Zebrafish (Danio rerio) Early Life Stage

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCenter for Evaluation of Environmental Impact on Human Health (TOXICAM)-
Autor(es): dc.creatorBertoni, Ítalo-
Autor(es): dc.creatorSales, Bianca Camargo Penteado-
Autor(es): dc.creatorViriato, Cristina-
Autor(es): dc.creatorPeixoto, Paloma Vitória Lima-
Autor(es): dc.creatorPereira, Lílian Cristina-
Data de aceite: dc.date.accessioned2025-08-21T23:18:32Z-
Data de disponibilização: dc.date.available2025-08-21T23:18:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/toxics12040255-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297368-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297368-
Descrição: dc.descriptionTriclopyr, an auxin-like herbicide that is widely employed for managing weeds in food crops and pastures, has been identified in various environmental settings, particularly aquatic ecosystems. Limited understanding of the environmental fate of this herbicide, its potential repercussions for both the environment and human health, and its insufficient monitoring in diverse environmental compartments has caused it to be recognized as an emerging contaminant of concern. In this study, we have investigated how triclopyr affects zebrafish, considering a new alternative methodology. We focused on the endpoints of developmental toxicity, neurotoxicity, and behavior of zebrafish embryos and larvae. We determined that triclopyr has a 96 h median lethal concentration of 87.46 mg/L (341.01 µM). When we exposed zebrafish embryos to sublethal triclopyr concentrations (0.5, 1, 5, 10, and 50 μM) for up to 144 h, we found that 50 µM triclopyr delayed zebrafish egg hatchability. Yolk sac malabsorption was significant at 0.5, 1, 5, and 10 µM triclopyr. In zebrafish larvae, uninflated swim bladder was significant only at 50 µM triclopyr. Furthermore, zebrafish larvae had altered swimming activity after exposure to 10 µM triclopyr for 144 h. In summary, these comprehensive results indicate that even low triclopyr concentrations can elicit adverse effects during early zebrafish development.-
Descrição: dc.descriptionMedical School São Paulo State University (Unesp)-
Descrição: dc.descriptionCenter for Evaluation of Environmental Impact on Human Health (TOXICAM)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Agriculture São Paulo State University (Unesp)-
Descrição: dc.descriptionMedical School São Paulo State University (Unesp)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Agriculture São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationToxics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcontaminant of emerging concern-
Palavras-chave: dc.subjectembryotoxicity-
Palavras-chave: dc.subjectnew methodology approach-
Palavras-chave: dc.subjecttriclopyr-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titleEmbryotoxicity Induced by Triclopyr in Zebrafish (Danio rerio) Early Life Stage-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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