Assessing different metrics of pedigree and genomic inbreeding and inbreeding effect on growth, fertility, and feed efficiency traits in a closed-herd Nellore cattle population

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstitute of Animal Science-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPurdue University-
Autor(es): dc.contributorFederal University of Viçosa-
Autor(es): dc.creatorBem, Ricardo D.-
Autor(es): dc.creatorBenfica, Lorena F.-
Autor(es): dc.creatorSilva, Delvan A.-
Autor(es): dc.creatorCarrara, Eula R.-
Autor(es): dc.creatorBrito, Luiz F.-
Autor(es): dc.creatorMulim, Henrique A.-
Autor(es): dc.creatorBorges, Marcelo S.-
Autor(es): dc.creatorCyrillo, Joslaine N. S. G.-
Autor(es): dc.creatorCanesin, Roberta C.-
Autor(es): dc.creatorBonilha, Sarah F. M.-
Autor(es): dc.creatorMercadante, Maria E. Z.-
Data de aceite: dc.date.accessioned2025-08-21T15:52:55Z-
Data de disponibilização: dc.date.available2025-08-21T15:52:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12864-024-10641-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297363-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297363-
Descrição: dc.descriptionBackground: The selection of individuals based on their predicted breeding values and mating of related individuals can increase the proportion of identical-by-descent alleles. In this context, the objectives of this study were to estimate inbreeding coefficients based on alternative metrics and data sources such as pedigree (FPED), hybrid genomic relationship matrix H (FH), and ROH of different length (FROH); and calculate Pearson correlations between the different metrics in a closed Nellore cattle population selected for body weight adjusted to 378 days of age (W378). In addition to total FROH (all classes) coefficients were also estimated based on the size class of the ROH segments: FROH1 (1–2 Mb), FROH2 (2–4 Mb), FROH3 (4–8 Mb), FROH4 (8–16 Mb), and FROH5 (> 16 Mb), and for each chromosome (FROH_CHR). Furthermore, we assessed the effect of each inbreeding metric on birth weight (BW), body weights adjusted to 210 (W210) and W378, scrotal circumference (SC), and residual feed intake (RFI). We also evaluated the chromosome-specific effects of inbreeding on growth traits. Results: The correlation between FPED and FROH was 0.60 while between FH and FROH and FH and FPED were 0.69 and 0.61, respectively. The annual rate of inbreeding was 0.16% for FPED, 0.02% for FH, and 0.16% for FROH. A 1% increase in FROH5 resulted in a reduction of up to -1.327 ± 0.495 kg in W210 and W378. Four inbreeding coefficients (FPED, FH, FROH2, and FROH5) had a significant effect on W378, with reductions of up to -3.810 ± 1.753 kg per 1% increase in FROH2. There was an unfavorable effect of FPED on RFI (0.01 ± 0.0002 kg dry matter/day) and of FROH on SC (-0.056 ± 0.022 cm). The FROH_CHR coefficients calculated for BTA3, BTA5, and BTA8 significantly affected the growth traits. Conclusions: Inbreeding depression was observed for all traits evaluated. However, these effects were greater for the criterion used for selection of the animals (i.e., W378). The increase in the genomic inbreeding was associated with a higher inbreeding depression on the traits evaluated when compared to pedigree-based inbreeding. Genomic information should be used as a tool during mating to optimize control of inbreeding and, consequently, minimize inbreeding depression in Nellore cattle.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Animal Science, SP-
Descrição: dc.descriptionDepartment of Animal Science Faculty of Agricultural and Veterinary Sciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Animal Sciences Purdue University, 270 S. Russell Street-
Descrição: dc.descriptionDepartment of Animal Sciences Federal University of Viçosa, MG-
Descrição: dc.descriptionDepartment of Pathology Reproduction and One Health Faculty of Agricultural and Veterinary Sciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Animal Science Faculty of Agricultural and Veterinary Sciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Pathology Reproduction and One Health Faculty of Agricultural and Veterinary Sciences Sao Paulo State University, SP-
Descrição: dc.descriptionCAPES: 0001-
Descrição: dc.descriptionFAPESP: 2017/10630-2-
Descrição: dc.descriptionCNPq: 434681/2018-0-
Idioma: dc.languageen-
Relação: dc.relationBMC Genomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeef cattle-
Palavras-chave: dc.subjectBos indicus-
Palavras-chave: dc.subjectCattle genome-
Palavras-chave: dc.subjectChromosomal inbreeding-
Palavras-chave: dc.subjectGenomic inbreeding-
Palavras-chave: dc.subjectInbreeding depression-
Título: dc.titleAssessing different metrics of pedigree and genomic inbreeding and inbreeding effect on growth, fertility, and feed efficiency traits in a closed-herd Nellore cattle population-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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