Expression of MicroRNAs in Adults with Celiac Disease: A Narrative Review

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBotucatu Technology Park-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorRigo, Francielen Furieri-
Autor(es): dc.creatorOliveira, Ellen Cristina Souza de-
Autor(es): dc.creatorQuaglio, Ana Elisa Valencise-
Autor(es): dc.creatorMoutinho, Bruna Damásio-
Autor(es): dc.creatorDi Stasi, Luiz Claudio-
Autor(es): dc.creatorSassaki, Ligia Yukie-
Data de aceite: dc.date.accessioned2025-08-21T19:53:12Z-
Data de disponibilização: dc.date.available2025-08-21T19:53:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25179412-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297332-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297332-
Descrição: dc.descriptionCeliac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of proline- and glutamine-rich proteins, widely termed “gluten”, in genetically susceptible individuals. CD induces an altered immune response that leads to chronic inflammation and duodenal mucosal damage. Currently, there are no specific tests for the accurate diagnosis of CD, and no drugs are available to treat this condition. The only available treatment strategy is lifelong adherence to a gluten-free diet. However, some studies have investigated the involvement of microRNAs (miRNAs) in CD pathogenesis. miRNAs are small noncoding ribonucleic acid molecules that regulate gene expression. Despite the growing number of studies on the role of miRNAs in autoimmune disorders, data on miRNAs and CD are scarce. Therefore, this study aimed to perform a literature review to summarize CD, miRNAs, and the potential interactions between miRNAs and CD in adults. This review shows that miRNA expression can suppress or stimulate pathways related to CD pathogenesis by regulating cell proliferation and differentiation, regulatory T-cell development, innate immune response, activation of the inflammatory cascade, focal adhesion, T-cell commitment, tissue transglutaminase synthesis, and cell cycle. Thus, identifying miRNAs and their related effects on CD could open new possibilities for diagnosis, prognosis, and follow-up of biomarkers.-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionVerum Ingredients Botucatu Technology Park, SP-
Descrição: dc.descriptionDepartment of Gastroenterology Division of Clinical Gastroenterology and Hepatology University of São Paulo School of Medicine (USP), SP-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTec) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTec) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectceliac disease-
Palavras-chave: dc.subjectgluten-free diet-
Palavras-chave: dc.subjectimmune response-
Palavras-chave: dc.subjectmicroRNAs-
Título: dc.titleExpression of MicroRNAs in Adults with Celiac Disease: A Narrative Review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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