Ascorbic acid as a modulator of inflammatory response against Candida albicans

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIndiana University School of Dentistry-
Autor(es): dc.creatorMoreira Milhan, Noala Vicensoto-
Autor(es): dc.creatorGraça Sampaio, Aline da-
Autor(es): dc.creatorKoga-Ito, Cristiane Yumi-
Autor(es): dc.creatorBruzzaniti, Angela-
Data de aceite: dc.date.accessioned2025-08-21T16:08:28Z-
Data de disponibilização: dc.date.available2025-08-21T16:08:28Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/fmb-2023-0188-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297302-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297302-
Descrição: dc.descriptionAim: To evaluate the behavior of oral keratinocytes in the presence of Vitamin C (Vit C) and its anti-inflammatory potential. Materials & methods: Oral keratinocytes were initially exposed to 0.1–2.5 mM of Vit C and the metabolic activity and cell migration were evaluated using MTS assay and Ibidi culture inserts, respectively. After, the cells were challenged with Candida albicans and inflammatory markers were analyzed by qPCR. Results: The treatment was not cytotoxic, and the highest concentrations increased the metabolic activity at 24 h. Vit C delayed the cell migration at 48 and 72 h. Interestingly, it downregulated the genes IL-8 and IL-1β. Conclusion: Vit C could be an interesting adjuvant to anti-fungal treatment due to its anti-inflammatory potential.-
Descrição: dc.descriptionDepartment of Environmental Engineering & Sciences Applied in Oral Health Graduate Program State University (Unesp) Institute of Science & Technology São José dos Campos-
Descrição: dc.descriptionDepartment of Biomedical & Applied Sciences Indiana University School of Dentistry-
Descrição: dc.descriptionDepartment of Environmental Engineering & Sciences Applied in Oral Health Graduate Program State University (Unesp) Institute of Science & Technology São José dos Campos-
Formato: dc.format585-594-
Idioma: dc.languageen-
Relação: dc.relationFuture Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-inflammatory-
Palavras-chave: dc.subjectascorbic acid-
Palavras-chave: dc.subjectcandidiasis-
Palavras-chave: dc.subjectinfection model-
Palavras-chave: dc.subjectvitamin C-
Título: dc.titleAscorbic acid as a modulator of inflammatory response against Candida albicans-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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