Sustainable Dry Crude Pomegranate Peel Extract as a Bio-input for Medicinal Gels: A Promising Alternative for Wound Healing

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Autor(es): dc.contributorFederal University of Espírito Santo (UFES)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Melo, Rita Cristina Gonçalves-
Autor(es): dc.creatorMantovanelli, Vitória Ribeiro-
Autor(es): dc.creatorde Paula, Geanne Aparecida-
Autor(es): dc.creatorFerreira, Daiana Freitas-
Autor(es): dc.creatorRomagna, Rodrigo de Almeida-
Autor(es): dc.creatorMonteiro, Jéssica Raquel Borges-
Autor(es): dc.creatorSantos, Mário Ferreira Conceição-
Autor(es): dc.creatorSeveri, Juliana Aparecida-
Autor(es): dc.creatorResende, Juliana Alves-
Autor(es): dc.creatorBoeloni, Jankerle Neves-
Autor(es): dc.creatorKitagawa, Rodrigo Rezende-
Autor(es): dc.creatorMeira, Eduardo Frizzera-
Autor(es): dc.creatorVillanova, Janaina Cecília Oliveira-
Data de aceite: dc.date.accessioned2025-08-21T19:15:14Z-
Data de disponibilização: dc.date.available2025-08-21T19:15:14Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/cbdv.202402710-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297238-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297238-
Descrição: dc.descriptionThe sustainable use of pomegranate peel, a by-product of the food industry, is gaining importance in developing pharmaceutical bio-inputs, aligning with circular economy practices and waste reduction. This study explores the application of dry crude pomegranate peel extract (PPE) as a bio-input for medicinal gels with wound healing properties. PPE was extracted via percolation in ethanol and freeze-dried. High-performance liquid chromatography and mass spectrometry identified key bioactive compounds: gallic acid, punicalagin, punicalin, ellagic acid, and citric acid, recognized for their antioxidant, antimicrobial, and healing properties. In vitro assays revealed low hemolytic activity, non-cytotoxicity, significant fibroblast proliferation, and robust antioxidant activity (95.99% 2,2-diphenyl-1-picrylhydrazyl scavenging at 100 µg/mL). A carbomer gel containing 2.5% w/w of the extract effectively promoted wound healing in rats, with performance comparable to that of silver sulfadiazine ointment, while demonstrating no microbial contamination during the process. These findings position PPE as a promising, sustainable, and effective alternative for wound-care pharmacotherapy, addressing both medical needs and environmental sustainability.-
Descrição: dc.descriptionPharmaceutical Product Development Laboratory Center of Exact Natural and Health Sciences Federal University of Espírito Santo (UFES)-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences - São Paulo State University (UNESP)-
Descrição: dc.descriptionGraduate Program in Veterinary Sciences Center for Agricultural Sciences and Engineering Federal University of Espírito Santo (UFES)-
Descrição: dc.descriptionGraduate Program in Pharmaceutical Sciences Center of Health Sciences Federal University of Espírito Santo (UFES)-
Descrição: dc.descriptionDepartment of Pharmacy and Nutrition Center of Exact Natural and Health Sciences Federal University of Espírito Santo (UFES)-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences - São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationChemistry and Biodiversity-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectpharmaceutical bio-input | pomegranate peel | re-epithelization | scratch assay-
Título: dc.titleSustainable Dry Crude Pomegranate Peel Extract as a Bio-input for Medicinal Gels: A Promising Alternative for Wound Healing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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