Genomic and epidemiological surveillance of SARS-CoV-2 variants during the pre-mass vaccination period in Botucatu, Brazil

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKansas State University-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.creatorda Costa, Felipe Allan da Silva-
Autor(es): dc.creatorAssato, Patricia Akemi-
Autor(es): dc.creatorTasca, Karen Ingrid-
Autor(es): dc.creatorde Moraes, Leonardo Nazário-
Autor(es): dc.creatordos Santos Figueiredo, Drielle Baptista-
Autor(es): dc.creatorRibeiro, Gabriela-
Autor(es): dc.creatorLima, Alex Ranieri Jerônimo-
Autor(es): dc.creatorSampaio, Sandra Coccuzzo-
Autor(es): dc.creatorElias Sabbaga, Maria Carolina Quartim Barbosa-
Autor(es): dc.creatorFortaleza, Carlos Magno Castelo Branco-
Autor(es): dc.creatorde Souza-Neto, Jayme Augusto-
Autor(es): dc.creatorGrotto, Rejane Maria Tommasini-
Data de aceite: dc.date.accessioned2025-08-21T22:25:39Z-
Data de disponibilização: dc.date.available2025-08-21T22:25:39Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11262-025-02137-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297201-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297201-
Descrição: dc.descriptionThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused an unprecedented pandemic in human history. To date, more than 6.5 million lives have been lost to COVID-19 (coronavirus disease 2019). Following widespread efforts for COVID-19 vaccination in Brazil, there has been a drastic reduction in COVID-19 deaths, which was particularly evident in the city of Botucatu, SP, Brazil, after a campaign to a mass vaccination. Our objective was to assess the temporal and epidemiological spread of variants of concern (VOC) of SARS-CoV-2 in the four weeks preceding the massive vaccination campaign in the municipality. After randomizing 400 samples, Next-Generation Sequencing was used to produce sequences and determine the variants. Among high-quality sequences, 98.4% belonged to the VOC Gamma, with P.1 and P.1.14 being the most prevalent lineages. P.1 was more frequent in both men and women, and in younger individuals and adults (0–59 years) compared to P.1.14. There was no correlation between the variants and the presence of comorbidities or between them and moderate to severe clinical cases of COVID-19 or death. However, P.1 was more frequent than P.1.14 in people with mild forms of the disease and in those who exhibited symptoms. In the phylogenetic analyses, a small cluster of 9 P.1.14 samples containing mutations in ORF1a: M584V and A3620V was observed, which had not been found in any Gamma sequences to date. The importance of genomic surveillance of SARS-CoV-2 is evident in assisting public health decision-making and the management of COVID-19 and other diseases.-
Descrição: dc.descriptionSchool of Agricultural Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Diagnostic Medicine/Pathobiology Kansas State University-
Descrição: dc.descriptionMedical School São Paulo State University (Unesp), SP-
Descrição: dc.descriptionClinical Hospital of the Botucatu Medical School, Av. Professor Mário Rubens Guimarães Montenegro, No Number-Jardim São José, SP-
Descrição: dc.descriptionButantan Institute, SP-
Descrição: dc.descriptionKansas State Veterinary Diagnostic Laboratory Kansas State University, 1800 Denison Ave-
Descrição: dc.descriptionSchool of Agricultural Sciences São Paulo State University (Unesp), SP-
Descrição: dc.descriptionMedical School São Paulo State University (Unesp), SP-
Descrição: dc.descriptionClinical Hospital of the Botucatu Medical School, Av. Professor Mário Rubens Guimarães Montenegro, No Number-Jardim São José, SP-
Idioma: dc.languageen-
Relação: dc.relationVirus Genes-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19 vaccination-
Palavras-chave: dc.subjectGenomic mutation tracking-
Palavras-chave: dc.subjectGenomic surveillance-
Palavras-chave: dc.subjectSARS-CoV-2 variants-
Palavras-chave: dc.subjectVaccination impact-
Título: dc.titleGenomic and epidemiological surveillance of SARS-CoV-2 variants during the pre-mass vaccination period in Botucatu, Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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