Liposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Católica de Santa María-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorKing's College London-
Autor(es): dc.contributorUniversity College London-
Autor(es): dc.creatorMaringolo Ribeiro, Camila-
Autor(es): dc.creatorCesar Augusto, Roque-Borda-
Autor(es): dc.creatorCarolina Franzini, Maria-
Autor(es): dc.creatorFernanda Manieri, Karyn-
Autor(es): dc.creatorManaia Demarqui, Fernanda-
Autor(es): dc.creatorLeite Campos, Débora-
Autor(es): dc.creatorTemperani Amaral Machado, Rachel-
Autor(es): dc.creatorCristiane da Silva, Isabel-
Autor(es): dc.creatorTavares Luiz, Marcela-
Autor(es): dc.creatorDelello Di Filippo, Leonardo-
Autor(es): dc.creatorBento da Silva, Patrícia-
Autor(es): dc.creatorCristina Oliveira da Rocha, Márcia-
Autor(es): dc.creatorNair Báo, Sônia-
Autor(es): dc.creatorMasci, Domiziana-
Autor(es): dc.creatorFernandes, Guilherme F.S.-
Autor(es): dc.creatorCastagnolo, Daniele-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorRogério Pavan, Fernando-
Data de aceite: dc.date.accessioned2025-08-21T16:26:25Z-
Data de disponibilização: dc.date.available2025-08-21T16:26:25Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2024.124050-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297150-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297150-
Descrição: dc.descriptionTuberculosis (TB) is an infectious disease that annually affects millions of people, and resistance to available antibiotics has exacerbated this situation. Another notable characteristic of Mycobacterium tuberculosis, the primary causative agent of TB, is its ability to survive inside macrophages, a key component of the immune system. In our quest for an effective and safe treatment that facilitates the targeted delivery of antibiotics to the site of infection, we have proposed a nanotechnology approach based on an iron chelator. Iron chelators are the primary mechanism by which bacteria acquire iron, a metal essential for their metabolism. Four liposomes were synthesized and characterized using the dynamic light scattering technique (DLS), nanoparticle tracking analysis (NTA), and transmission electron microscopy (TEM). All of these methods revealed the presence of spherical particles, approximately 200 nm in size. NTA indicated a concentration of around 1011 particles/mL. We also developed and validated a high-performance liquid chromatography method for quantifying Moxifloxacin to determine encapsulation efficiency (EE) and release profiles (RF). The EE was 51.31 % for LipMox and 45.76 % for LipIchMox. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) confirmed the phagocytosis of liposomal vesicles by macrophages. Functionalizing liposomes with iron chelators can offer significant benefits for TB treatment, such as targeted drug delivery to intracellular bacilli through the phagocytosis of liposomal particles by cells like macrophages.-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory, São Paulo-
Descrição: dc.descriptionVicerrectorado de Investigación Universidad Católica de Santa María-
Descrição: dc.descriptionCell Biology Department Institute of Biological Sciences University of Brasilia-
Descrição: dc.descriptionInstitute of Pharmaceutical Science School of Cancer & Pharmaceutical Science King's College London, 150 Stamford Street-
Descrição: dc.descriptionDepartment of Chemistry University College London, 20 Gordon Street-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
???dc.source???: dc.sourceScopus-
Título: dc.titleLiposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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