Toxicological effects of the Curatella americana extract in embryo development of female pups from diabetic rats

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Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCruz, Larissa Lopes-
Autor(es): dc.creatorBarco, Vinícius Soares-
Autor(es): dc.creatorPaula, Verônyca Gonçalves-
Autor(es): dc.creatorSouza, Maysa Rocha-
Autor(es): dc.creatorGallego, Franciane Quintanilha-
Autor(es): dc.creatorMonteiro, Gean Charles-
Autor(es): dc.creatorLima, Giuseppina Pace Pereira-
Autor(es): dc.creatorDamasceno, Débora Cristina-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T17:45:05Z-
Data de disponibilização: dc.date.available2025-08-21T17:45:05Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.repbio.2023.100819-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297119-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297119-
Descrição: dc.descriptionMaternal diabetes can influence the development of offspring during fetal life and postnatally. Curatella americana is a plant used as a menstrual cycle regulator and to prevent diabetes. This study evaluates the effects of C. americana aqueous extract on the estrous cycle and preimplantation embryos of adult female pups from diabetic rats. Female Sprague Dawley newborn rats received Streptozotocin or vehicle (citrate buffer). At adulthood, were submitted to the Oral Glucose Tolerance Test, and mated. The female rats were obtained and were distributed into four experimental groups: OC and OC/T represent female pups of control mothers and received water or plant extract, respectively; OD and OD/T represent female pups of diabetic mothers and received water or plant extract, respectively. The estrous cycle was followed for 10 days, the rats were mated and on gestational day 4 was performed preimplantation embryo analysis. Phenolic composition and biogenic amines in the extract were analyzed about the influence of the thermal process. The female pups from diabetic dams exhibited glucose intolerance, irregular estral cycle and a higher percentage of pre-embryos in delayed development (morula stage). After C. americana treatment, OD/T group no present a regular estrous cycle. Furthermore, the infusion process increases phenolic compounds and biogenic amines levels, which can have anti-estrogenic effect, anticipates the early embryonic development, and impair pre-implantation embryos. Thus, the indiscriminate use of medicinal plants should be avoided in any life phases by women, especially during pregnancy.-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Bioscience São Paulo State University-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Bioscience São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationReproductive Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBlastocyst-
Palavras-chave: dc.subjectDOHaD-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectMedicinal plant-
Palavras-chave: dc.subjectPolyamines-
Título: dc.titleToxicological effects of the Curatella americana extract in embryo development of female pups from diabetic rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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