Cytogenotoxic screening of the natural compound niga-ichigoside F1 from Rubus imperialis (Rosaceae)

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Autor(es): dc.contributorMarilia Medical School (FAMEMA)-
Autor(es): dc.contributorVale do Itajaí University (UNIVALI)-
Autor(es): dc.contributorUniversity of Trás-os-Montes and Alto Douro-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAlmeida-Terassi, Laíza Moura-
Autor(es): dc.creatorCastanha, Ana Paula Martins-
Autor(es): dc.creatorAlves, Greice Rafaele-
Autor(es): dc.creatorCechinel-Filho, Valdir-
Autor(es): dc.creatorNiero, Rivaldo-
Autor(es): dc.creatorO'Neill de Mascarenhas Gaivão, Isabel-
Autor(es): dc.creatorde Oliveira, Liana Martins-
Autor(es): dc.creatorde Lima, Luan Vitor Alves-
Autor(es): dc.creatorMantovani, Mário Sérgio-
Autor(es): dc.creatorMaistro, Edson Luis-
Data de aceite: dc.date.accessioned2025-08-21T22:43:09Z-
Data de disponibilização: dc.date.available2025-08-21T22:43:09Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jat.4608-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297115-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297115-
Descrição: dc.descriptionRubus imperialis Chum. Schl. (Rosaceae) have demonstrated some pharmacological activities, including gastroprotective action. However, genotoxic effects of R. imperialis extract was also reported. Since niga-ichigoside F1 (NIF1) is a major compound of this plant species, and which has proven pharmacological properties, it is essential to investigate whether this compound is responsible for the observed toxicity. Therefore, the objective of this study was to analyze the effects of NIF1 on HepG2/C3A cells for possible cytogenotoxicity, cell cycle and apoptosis influence, and expression of genes linked to the DNA damage, cell cycle, cell death, and xenobiotic metabolism. The results showed no cytogenotoxic effects of NIF1 at concentrations between 0.1 and 20 μg/ml. Flow cytometry also showed no cell cycle or apoptosis disturbance. In the gene expression analysis, none of the seven genes investigated showed altered expression. The data indicate that NIF1 has no cytogenotoxic effects, and no interruption of the cell cycle, or induction of apoptosis, apparently not being responsible for the cytotoxic effects observed in the crude extract of R. imperialis.-
Descrição: dc.descriptionPostgraduate Program in Health and Aging Marilia Medical School (FAMEMA), São Paulo State-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR) Vale do Itajaí University (UNIVALI), Santa Catarina State-
Descrição: dc.descriptionCECAV and Department of Genetics and Biotechnology University of Trás-os-Montes and Alto Douro-
Descrição: dc.descriptionDepartment of General Biology Londrina State University (UEL), Paraná State-
Descrição: dc.descriptionFaculty of Philosophy and Sciences Speech and Hearing Therapy Department São Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionFaculty of Philosophy and Sciences Speech and Hearing Therapy Department São Paulo State University (UNESP), São Paulo State-
Formato: dc.format1129-1138-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectapoptosis analysis-
Palavras-chave: dc.subjectcell cycle analysis-
Palavras-chave: dc.subjectcomet assay-
Palavras-chave: dc.subjectgene expression-
Palavras-chave: dc.subjectmicronucleus test-
Palavras-chave: dc.subjectNiga-ichigoside F1 toxicity-
Título: dc.titleCytogenotoxic screening of the natural compound niga-ichigoside F1 from Rubus imperialis (Rosaceae)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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