Enantioselective analysis of the pesticide imazamox after in vitro permeability study in Caco-2 cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorELEVE Science-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSerpellone, Carolina Oliveira-
Autor(es): dc.creatorBarbetta, Maike Felipe Santos-
Autor(es): dc.creatorPerovani, Icaro Salgado-
Autor(es): dc.creatorBallestero, Giulia-
Autor(es): dc.creatorde Albuquerque, Nayara Cristina Perez-
Autor(es): dc.creatorde Oliveira, Anderson Rodrigo Moraes-
Data de aceite: dc.date.accessioned2025-08-21T16:21:42Z-
Data de disponibilização: dc.date.available2025-08-21T16:21:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/elps.202300193-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297106-
Descrição: dc.descriptionImazamox (IMX), a chiral herbicide used in cereals and oilseed crops to control weeds, is commonly sold as a racemic mixture. Its enantiomers, being chiral compounds, may exhibit unique properties when exposed to chiral environments. While IMX enantiomers have been reported to degrade differently in soil and be toxic to some species, their effects on human systems remain poorly understood. This study utilized Caco-2 (human colon adenocarcinoma cell line) cells to assess the in vitro permeability of a racemic mixture of IMX and its isolated enantiomers. Additionally, the study aimed to evaluate whether the metabolite imazamox-O-desmethyl (IMX-D) forms during the permeability process. An enantioselective chromatographic method was developed, fully validated, and the apparent permeability values were obtained. The apparent permeability of rac-IMX, (+)-IMX, and (−)-IMX was determined to be 4.15 × 10–5, 5.78 × 10–5, and 7.33 × 10–5cm s–1, respectively. These findings suggest that IMX exhibits high intestinal permeability, with an enantioselective absorption for (–)-IMX as compared to (+)-IMX. Finally, the permeability study in Caco-2 cells revealed that the metabolite IMX-D was not generated.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo-
Descrição: dc.descriptionLaboratory of Research Development and Innovation ELEVE Science, São Paulo-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Unesp Institute of Chemistry, São Paulo-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Unesp Institute of Chemistry, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/50945-4-
Descrição: dc.descriptionFAPESP: 2021/10098-4-
Descrição: dc.descriptionCNPq: 306186/2021-7-
Descrição: dc.descriptionCNPq: 465571/2014-0-
Descrição: dc.descriptionCNPq: INCT-DATREM-
Formato: dc.format1033-1040-
Idioma: dc.languageen-
Relação: dc.relationElectrophoresis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaco-2 cells-
Palavras-chave: dc.subjectchiral HPLC-
Palavras-chave: dc.subjectimazamox-
Palavras-chave: dc.subjectpermeability-
Palavras-chave: dc.subjectpesticide-
Título: dc.titleEnantioselective analysis of the pesticide imazamox after in vitro permeability study in Caco-2 cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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