Retinol-binding protein 4 is a potential biomarker of changes in lean mass in postmenopausal women

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Autor(es): dc.contributorFederal University of Triangulo Mineiro (UFTM)-
Autor(es): dc.contributorOeste Paulista University (UNOESTE)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Queiroz Freitas, Augusto Corrêa-
Autor(es): dc.creatorOrsatti, Cláudio Lera-
Autor(es): dc.creatorSantato, Alexia Souza-
Autor(es): dc.creatorde Oliveira, Erick P.-
Autor(es): dc.creatorNahas, Eliana A. P.-
Autor(es): dc.creatorSouza, Markus Vinicius Campos-
Autor(es): dc.creatorOrsatti, Fábio Lera-
Data de aceite: dc.date.accessioned2025-08-21T21:23:26Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:26Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1139/apnm-2024-0156-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297102-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297102-
Descrição: dc.descriptionIdentifying biomarkers can help in the early detection of muscle loss and drive the development of new therapies. Research suggests a potential link between retinol-binding protein 4 (RBP4) and muscle mass, particularly in postmenopausal women. This study aimed to examine the association between baseline RBP4 levels and changes in appendicular lean mass (ALM), an indicator of muscle mass, in postmenopausal women. A 12-month follow-up period (n = 153) included baseline and 12-month ALM assessments using DXA. ALM was normalized to squared height (ALMI). Baseline evaluations encompassed insulin resistance via HOMA-IR and immunoassay magnetic bead panel measurements of RPB4, IL-6, TNF-α, and IL-10. Postmenopausal women were categorized into higher (n = 77) and lower (n = 76) RPB4 groups based on baseline RPB4 values. Their changes in ALMI were compared using Mann–Whitney tests. General linear model was employed to evaluate the predictive power of baseline RBP4 for ALMI changes, adjusting for confounding variables: age, physical activity, smoking status, body fat, HOMA-IR, inflammatory markers (TNF-α and IL-6), and anti-inflammatory factor (IL-10). The higher RBP4 group exhibited a more pro-nounced reduction in ALMI compared to the lower RBP4 group (Higher RBP4 = −0.39 kg/m2, 95% CI: −0.48 to −0.31 kg/m2 vs. Lower RBP4 = −0.24 kg/m2, 95% CI: −0.32 to −0.15 kg/m2, P = 0.011). After adjusting for confounding factors, the association between baseline RBP4 changes and ALMI remained (b = −0.008, SE = 0.002, P < 0.001), indicating higher baseline RBP4 values linked to greater ALMI reduction. Our findings support RBP4 as a potential biomarker for changes in muscle mass in postmenopausal women.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionApplied Physiology Nutrition and Exercise Research Group (PhyNEr) Exercise Biology Laboratory (BioEx) Institute of Health Sciences Federal University of Triangulo Mineiro (UFTM), Minas Gerais-
Descrição: dc.descriptionDepartment Health Science Oeste Paulista University (UNOESTE), SP-
Descrição: dc.descriptionLaboratory of Nutrition Exercise and Health (LaNES) School of Medicine Federal University of Uberlandia-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format1551-1557-
Idioma: dc.languageen-
Relação: dc.relationApplied Physiology, Nutrition and Metabolism-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectALMI changes-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectpostmenopausal women-
Palavras-chave: dc.subjectRBP4-
Título: dc.titleRetinol-binding protein 4 is a potential biomarker of changes in lean mass in postmenopausal women-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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