Serum levels of oxidative stress biomarkers is changed in pharmacoresistant mesial temporal lobe epilepsy patients with or without psychiatric disorders

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFaculdade de Medicina de Sao Jose do Rio Preto (FAMERP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Paulista (UNIP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLopes, Angélica Marta-
Autor(es): dc.creatorBuosi, Patrick-
Autor(es): dc.creatorFarina, Bruna de Mattos-
Autor(es): dc.creatorFernandes-Ferreira, Rafael-
Autor(es): dc.creatorOliveira-Brancati, Camila Ive Ferreira-
Autor(es): dc.creatorMartins, Denise Poltronieri-
Autor(es): dc.creatorda Silva, Danilo Grünig Humberto-
Autor(es): dc.creatorChaves, Nayara Alves-
Autor(es): dc.creatorMarques, Lucia Helena Neves-
Autor(es): dc.creatorFilho, Gerardo Maria de Araújo-
Autor(es): dc.creatorSouza, Dorotéia Rossi Silva-
Data de aceite: dc.date.accessioned2025-08-21T22:30:11Z-
Data de disponibilização: dc.date.available2025-08-21T22:30:11Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.dscb.2023.100099-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297080-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297080-
Descrição: dc.descriptionThe objective of the present study was to assess the levels of oxidative stress biomarkers (OSB) in patients with pharmacoresistant temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS) in order to investigate a possible role of oxidative stress (OS) in the pathophysiology of such disease. Ninety-eight participants were included and distributed in three groups: group 1 (G1) - 25 patients with pharmacoresistant TLE-MTS, without comorbid PD; Group 2 (G2) - 21 patients with pharmacoresistant TLE-MTS with PD; Group 3 (G3) - 52 healthy control subjects. Serum levels of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione plus oxidated glutathione (total GSH), glucose-6-phosphate dehydrogenase (G6PD), Trolox-equivalent antioxidant capacity (TEAC), and thiobarbituric acid reactive substances (TBARS) were analyzed through spectrometry. The significance level was set at P<0.05. Sociodemographic data were similar in all groups (P>0.05). A family history of epilepsy was more frequent among G1 and G2 groups when compared to G3 (P = 0.0002). Compared to controls, G1 and G2 presented higher CAT (P<0.0001) and TBARS levels (P = 0.001), as well as lower GPx (P<0.0001), G6PD (P = 0.005) and total GSH levels (P = 0.04). The presence of psychiatric disorders (PD), analyzed both separately and together, was not associated with significant differences in OSB levels (P>0.05). The lower levels of GPx, G6PD, and total GSH, as well as the higher CAT and TBARS levels observed in pharmaco-resistant TLE-MTS patients can indicate an imbalance between oxidizing agent production and elimination, supporting the hypothesis of a possible role of OS in the pathogenesis of this condition.-
Descrição: dc.descriptionDepartment of Molecular Biology Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP)-
Descrição: dc.descriptionFaculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP) Universidade de São Paulo (USP)-
Descrição: dc.descriptionUniversidade Estadual de Campinas (UNICAMP)-
Descrição: dc.descriptionUniversidade Paulista (UNIP), São José do Rio Preto-
Descrição: dc.descriptionUniversidade Federal de Mato Groso do Sul (UFMS/CPTL), Campus Três Lagoas-
Descrição: dc.descriptionUniversidade Estadual de São Paulo (UNESP/IBILCE), São José do Rio Preto-
Descrição: dc.descriptionDepartment of Neurological Sciences Psychiatry and Medical Psychology Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), Av. Brigadeiro Faria Lima, 5416 – Nova Redentora – São José do Rio Preto-
Descrição: dc.descriptionUniversidade Estadual de São Paulo (UNESP/IBILCE), São José do Rio Preto-
Idioma: dc.languageen-
Relação: dc.relationBrain Disorders-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMesial temporal sclerosis-
Palavras-chave: dc.subjectOxidative stress biomarkers-
Palavras-chave: dc.subjectPharmacoresistant epilepsy-
Palavras-chave: dc.subjectPsychiatric disorders-
Palavras-chave: dc.subjectTemporal lobe epilepsy-
Título: dc.titleSerum levels of oxidative stress biomarkers is changed in pharmacoresistant mesial temporal lobe epilepsy patients with or without psychiatric disorders-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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