Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorde Souza, Sérgio Luiz Borges-
Autor(es): dc.creatorMota, Gustavo Augusto Ferreira-
Autor(es): dc.creatorda Silva, Vitor Loureiro-
Autor(es): dc.creatorVileigas, Danielle Fernandes-
Autor(es): dc.creatorSant'Ana, Paula Grippa-
Autor(es): dc.creatorGregolin, Cristina Schmitt-
Autor(es): dc.creatorFigueira, Rebeca Lopes-
Autor(es): dc.creatorBatah, Sabrina Setembre-
Autor(es): dc.creatorFabro, Alexandre Todorovic-
Autor(es): dc.creatorMurata, Gilson Masahiro-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati-
Autor(es): dc.creatorOkoshi, Marina Politi-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T21:14:04Z-
Data de disponibilização: dc.date.available2025-08-21T21:14:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jcmm.17908-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297051-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297051-
Descrição: dc.descriptionWe employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with the amelioration of cardiac dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5-week sessions of treadmill running for 16 weeks. Statistical analysis was conducted by anova or Kruskal–Wallis test and Goodman test. A global correlation between variables was also performed using a two-tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis-induced heart failure.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Faculty of Medicine University of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School São Paulo State University-
Descrição: dc.descriptionFAPESP: 2015/16934/8-
Descrição: dc.descriptionCNPq: 305399/2015-2-
Descrição: dc.descriptionCNPq: 310284/2019-8-
Descrição: dc.descriptionCNPq: 421058/2018-8-
Descrição: dc.descriptionCNPq: 442822/2014-6-
Formato: dc.format2956-2969-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cellular and Molecular Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectangiogenesis-
Palavras-chave: dc.subjectaortic stenosis-
Palavras-chave: dc.subjectfatty acid oxidation-
Palavras-chave: dc.subjectphysical exercise-
Palavras-chave: dc.subjectpressure overload-
Palavras-chave: dc.subjectSIRT1-
Título: dc.titleEffects of early exercise on cardiac function and lipid metabolism pathway in heart failure-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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